The key role of coligands in novel ruthenium(II)-cyclopentadienyl bipyridine derivatives: ranging from non-cytotoxic to highly cytotoxic compounds


Autoria(s): Côrte-Real, Leonor; Robalo, Maria Paula; Marques, Fernanda; Nogueira, Guilherme; Avecilla, Fernando; Silva, Tiago J. L.; Santos, Filipa C.; Tomaz, A. Isabel; Garcia, Maria Helena; Valente, Andreia
Data(s)

19/04/2016

19/04/2016

01/09/2015

Resumo

A new family of eight ruthenium(II)-cyclopentadienyl bipyridine derivatives, bearing nitrogen, sulfur, phosphorous and carbonyl sigma bonded coligands, has been synthesized. Compounds bearing nitrogen bonded coligands were found to be unstable in aqueous solution, while the others presented appropriate stabilities for the biologic assays and pursued for determination of IC50 values in ovarian (A2780) and breast (MCF7 and MDAMB231) human cancer cell lines. These studies were also carried out for the [5: HSA] and [6: HSA] adducts (HSA=human serum albumin) and a better performance was found for the first case. Spectroscopic, electrochemical studies by cyclic voltammetry and density functional theory calculations allowed us to get some understanding on the electronic flow directions within the molecules and to find a possible clue concerning the structural features of coligands that can activate bipyridyl ligands toward an increased cytotoxic effect. X-ray structure analysis of compound [Ru(η(5)-C5H5)(bipy)(PPh3)][PF6] (7; bipy=bipyridine) showed crystallization on C2/c space group with two enantiomers of the [Ru(η(5)-C5H5)(bipy)(PPh3)](+) cation complex in the racemic crystal packing.

Identificador

CÔRTE-REAL, Leonor; [et al] - The key role of coligands in novel ruthenium(II)-cyclopentadienyl bipyridine derivatives: ranging from non-cytotoxic to highly cytotoxic compounds. Journal of Inorganic Biochemistry. ISSN 0162-0134. Vol. 150. 148-159, 2015

0162-0134

1873-3344

http://hdl.handle.net/10400.21/6050

10.1016/j.jinorgbio.2015.06.015

Idioma(s)

eng

Publicador

Elsevier Science INC

Direitos

closedAccess

Palavras-Chave #Ruthenium(II) #Cyclopentadienyl #Cyclic voltammetry #Electronic flow #Cytotoxicity
Tipo

article