Comparative study on the localization of adult Schistosoma mansoni worms in albino mice anesthetized with pentobarbital sodium, ether or chlorophorm


Autoria(s): Machado e Silva,José Roberto; Lima,Maria Adriana Dias de; Rodrigues e Silva,Rosângela; Maldonado Jr.,Arnaldo; Presgrave,Octávio Augusto França; Rey,Luis
Data(s)

01/08/1993

Resumo

The effect of anesthetic drugs on the localization of adult worms in albino mice was compared. The animals with 56 days of infection were anesthetized with pentobarbital sodium, ether or chlorophorm. Perfusion was carried out immediately after, recovering the worms and classifying them in relation to their localization on the liver or portal vein and the mesenteric veins. Our results showed that pentobarbital sodium produced a greater displacement of the worms to the liver (89%) than ether (76%) and chlorophorm (34%) did, when compared to the control group (22%). The difference between pentobarbital sodium and ether was significant (p < 0.05). We suggest that anesthetic drugs may not be used in studies on the distribution of adult worms in several hosts.

Formato

text/html

Identificador

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651993000400003

Idioma(s)

en

Publicador

Instituto de Medicina Tropical

Fonte

Revista do Instituto de Medicina Tropical de São Paulo v.35 n.4 1993

Palavras-Chave #Schistosoma mansoni #Schistosomiasis mansoni #localization #Anesthetics #Pentobarbital sodium #Ether #Chlorophorm
Tipo

journal article