Histological observations on Montenegro's reaction in man


Autoria(s): Mayrink,Wilson; Schettini,Antonio Pedro M.; Williams,Paul; Raso,Pedro; Magalhães,Paulo Araujo; Lima,Antonio De Oliveira; Melo,Maria Norma; Costa,Carlos Alberto da; Genaro,Odair; Dias,Magno; Michalick,Marilene Suzan Marques
Data(s)

01/08/1989

Resumo

The Montenegro skin test is widely used as a diagnostic method for American cutaneous leishmaniasis (ACL) but little is known about the histological changes that occur in the skin after administration of the antigen. This report is based on histological studies of biopsied material obtained, from inoculation sites, 48 hours after individuals had been given intradermal injections with a standardized Montenegro antigen. The material examined was obtained from four distinctly different test groups: naturally infected patients with parasitologically proved ACL and with positive Montenegro's reaction; individuals without previous history of ACL and not previously tested with Montenegro antigen; participants in anti-ACL vaccine trials who developed positive reactions to Montenegro antigen after vaccination; other participants in vaccine trials who had negative Montenegro responses after vaccination or had served as controls in the trials. The histological pictures of each group are described and discussed. Histologically, the reactions of vaccinated individuals were indistinguishable from those with naturally acquired infections.

Formato

text/html

Identificador

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651989000400008

Idioma(s)

en

Publicador

Instituto de Medicina Tropical

Fonte

Revista do Instituto de Medicina Tropical de São Paulo v.31 n.4 1989

Palavras-Chave #American Cutaneous leishmaniasis #Montenegro skin test #Histology of skin changes
Tipo

journal article