188Re-PEI-MP as potential agent for metabolic radiotherapy


Autoria(s): Ferreira, Sara; Abrantes, Ana Margarida; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene D.; Botelho, Maria Filomena
Data(s)

30/01/2015

30/01/2015

15/10/2010

Resumo

Introduction: 188Re is a promising radionuclide for metabolic therapy because of the emission of high energy beta-particles. The development of watersoluble bone-seeking polymers such as PEI-MP (polyethyleneimine, functionalised with methylphosphonate-groups) that might be labeled with 188Re are recent approaches, with a strong potential for bone cancer treatment. The aim of this study was to evaluate the efficacy of 188Re-PEI-MP, as therapeutic agent for osteosarcoma, through in vitro and in vivo models.

Identificador

http://hdl.handle.net/10400.22/5544

Idioma(s)

eng

Direitos

openAccess

Tipo

conferenceObject