Wound healing and cancer progression in Opisthorchis viverrini associated cholangiocarcinoma
| Data(s) |
24/05/2016
30/04/2016
01/06/2018
|
|---|---|
| Resumo |
Letter to the editor Infection with the human liver fluke Opisthorchis viverrini induces cancer of the bile ducts, cholangiocarcinoma (CCA). It was shown previously that O. viverrini-secreted proteins accelerate wound resolution in human cholangiocytes. Recombinant Ov-GRN-1 (O. viverrini-derived gene encoding granulin-like growth factor) induced angiogenesis and accelerated mouse wound healing. Given the striking similarities of wound healing and cancer progression, here we discuss the major implications of this finding for an infection-induced cancer of major public health significance in the developing world. This work was financed by FEDER–Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 - Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds. |
| Identificador |
Parasitol Res. 2016 Apr 30. [Epub ahead of print]. doi: 10.1007/s00436-016-5090-6 0932-0113 ESSN: 1432-1955 http://hdl.handle.net/10400.18/3802 10.1007/s00436-016-5090-6 |
| Idioma(s) |
eng |
| Publicador |
Springer Verlag (Germany) |
| Relação |
http://link.springer.com/article/10.1007%2Fs00436-016-5090-6 |
| Direitos |
embargoedAccess |
| Palavras-Chave | #Cholangiocarcinoma #Opisthorchis viverrini #Tumor Progression #Wound Healing |
| Tipo |
article |
