Two-locus Linkage Analysis Applied to Putative Quantitative Trait Loci for Lipoprotein(a) Levels

Autoria(s): Beekman, Marian; Heijmans, Bastiaan T.; Martin, Nicholas G.; Whitfield, John B.; Pedersen, Nancy L.; DeFaire, Ulf; Snieder, Harold; Lakenberg, Nico; Knijff, Peter; Frants, Rune R.; van Ommen, Gert Jan B.; Kluft, Cornelis; Vogler, George R.; Slagboom, P. Eline; Boomsma, Dorret I.
Contribuinte(s)

N. G. Martin

K. M. Kirk
Data(s)

01/01/2003
Resumo

Plasma levels of lipoprotein(a) _ Lp(a) _ are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs.
Identificador

http://espace.library.uq.edu.au/view/UQ:65029
Idioma(s)

eng
Publicador

Australian Academic Press
Palavras-Chave #Genetics & Heredity #Obstetrics & Gynecology #Reproductive Biology #Risk-factors #Apolipoprotein #Disease #C1 #321011 Medical Genetics #730107 Inherited diseases (incl. gene therapy)
Tipo

Journal Article
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