Intracellular sorting and transport of proteins


Autoria(s): van Vliet, Catherine; Thomas, Elaine C.; Merino-Trigo, Ana; Teasdale, Rohan D.; Gleeson, Paul A.
Contribuinte(s)

T. L. Blundell

D. Noble

Data(s)

01/09/2003

Resumo

The secretory and endocytic pathways of eukaryotic organelles consist of multiple compartments, each with a unique set of proteins and lipids. Specific transport mechanisms are required to direct molecules to defined locations and to ensure that the identity, and hence function, of individual compartments are maintained. The localisation of proteins to specific membranes is complex and involves multiple interactions. The recent dramatic advances in understanding the molecular mechanisms of membrane transport has been due to the application of a multi-disciplinary approach, intergrating membrane biology, genetics, imaging, protein and lipid biochemistry and structural biology. The aim of this review is to summarise the general principles of protein sorting in the secretory and endocytic pathways and to highlight the dynamic nature of these processes. The molecular mechanisms involved in this transport along the secretory and endocytic pathways are discussed along with the signals responsible for targeting proteins to different intracellular locations. (C) 2003 Elsevier Science Ltd. All rights reserved.

Identificador

http://espace.library.uq.edu.au/view/UQ:65025

Idioma(s)

eng

Publicador

Pergamon-Elsevier Science Ltd

Palavras-Chave #Biochemistry & Molecular Biology #Biophysics #Protein Sorting #Membrane Transport #Golgi Apparatus #Endosomes #Peripheral Membrane-protein #Polarized Epithelial-cells #Mannose 6-phosphate Receptors #Asparagine-linked Oligosaccharides #N-acetylglucosaminyltransferase-i #Pleckstrin-homology Domains #Soluble Secretory Proteins #Golgi Network Localization #Gtpase-activating Protein #Vesicle-tethering Protein #C1 #270104 Membrane Biology #780105 Biological sciences
Tipo

Journal Article