Diverse synaptic mechanisms generate direction selectivity in the rabbit retina


Autoria(s): Rowland Taylor, W.; Vaney, D. I.
Contribuinte(s)

D. Van Essen

Data(s)

01/09/2002

Resumo

The synaptic conductance of the On-Off direction-selective ganglion cells was measured during visual stimulation to determine whether the direction selectivity is a property of the circuitry presynaptic to the ganglion cells or is generated by postsynaptic interaction of excitatory and inhibitory inputs. Three synaptic asymmetries were identified that contribute to the generation of direction-selective responses: (1) a presynaptic mechanism producing stronger excitation in the preferred direction, (2) a presynaptic mechanism producing stronger inhibition in the opposite direction, and (3) postsynaptic interaction of excitation with spatially offset inhibition. Although the on- and off-responses showed the same directional tuning, the off-response was generated by all three mechanisms, whereas the on- response was generated primarily by the two presynaptic mechanisms. The results indicate that, within a single neuron, different strategies are used within distinct dendritic arbors to accomplish the same neural computation.

Identificador

http://espace.library.uq.edu.au/view/UQ:64283/UQ64283_OA.pdf

http://espace.library.uq.edu.au/view/UQ:64283

Idioma(s)

eng

Publicador

Society for Neuroscience

Palavras-Chave #Direction Selectivity #Ganglion Cells #Synaptic Conductance #Inhibition #Excitation #Dendritic Integration #On- And Off-pathways #Rabbit Retina #Starburst Amacrine Cells #Ganglion-cells #Dendritic Architecture #Conductance #Inhibition #Responses #Neurons #Input #Size #C1 #320702 Central Nervous System #730111 Hearing, vision, speech and their disorders #110903 Central Nervous System
Tipo

Journal Article