Neutrophil dysplasia characterised by a pseudo-Pelger-Huet anomaly occurring with the use of mycophenolate mofetil and ganciclovir following renal transplantation: a report of five cases
Contribuinte(s) |
Royal College of Pathologists of Australia |
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Data(s) |
01/06/2002
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Resumo |
Aim: The pseudo-Pelger-Huet (PH) anomaly has been associated with a variety of primary haematological disorders, infections and drugs. Recently, the development of dysgranulopoiesis characterised by a pseudo-PH anomaly has been reported in two patients with the use of mycophenolate mofetil (MMF) in the setting of heart and/or lung transplantation. We present a further five cases of MMF-related dysgranulopoiesis characterised by a pseudo-PH anomaly occurring after renal transplantation. Methods: All patients were receiving standard immunosuppression protocols for renal transplantation, including a combination of MMF, steroids and either cyclosporin or tacrolimus. Oral ganciclovir was also used for cytomegalovirus prophylaxis in each case. Results: Development of dysplastic granulopoiesis occurred a median of 96 days (range 66-196 days) after transplantation. Moderate or severe neutropaenia ( |
Identificador | |
Idioma(s) |
eng |
Publicador |
Taylor & Francis |
Palavras-Chave | #Pathology #Dysgranulopoiesis #Ganciclovir #Mycophenolate Mofetil #Neutropenia #Neutropaenia #Pseudo-pelger-huet Anomaly #Acid #Therapy #C1 #730115 Urogenital system and disorders #110312 Nephrology and Urology |
Tipo |
Journal Article |