Neutrophil dysplasia characterised by a pseudo-Pelger-Huet anomaly occurring with the use of mycophenolate mofetil and ganciclovir following renal transplantation: a report of five cases


Autoria(s): Kennedy, Glen A.; Kay, Troy D.; Johnson, D. W.; Hawley, Carmel M.; Campbell, Scott B.; Isbel, Nikky M..; Marlton, Paula; Cobcroft, Ralph; Gill, Devinder; Cull, Gavin
Contribuinte(s)

Royal College of Pathologists of Australia

Data(s)

01/06/2002

Resumo

Aim: The pseudo-Pelger-Huet (PH) anomaly has been associated with a variety of primary haematological disorders, infections and drugs. Recently, the development of dysgranulopoiesis characterised by a pseudo-PH anomaly has been reported in two patients with the use of mycophenolate mofetil (MMF) in the setting of heart and/or lung transplantation. We present a further five cases of MMF-related dysgranulopoiesis characterised by a pseudo-PH anomaly occurring after renal transplantation. Methods: All patients were receiving standard immunosuppression protocols for renal transplantation, including a combination of MMF, steroids and either cyclosporin or tacrolimus. Oral ganciclovir was also used for cytomegalovirus prophylaxis in each case. Results: Development of dysplastic granulopoiesis occurred a median of 96 days (range 66-196 days) after transplantation. Moderate or severe neutropaenia (

Identificador

http://espace.library.uq.edu.au/view/UQ:62335

Idioma(s)

eng

Publicador

Taylor & Francis

Palavras-Chave #Pathology #Dysgranulopoiesis #Ganciclovir #Mycophenolate Mofetil #Neutropenia #Neutropaenia #Pseudo-pelger-huet Anomaly #Acid #Therapy #C1 #730115 Urogenital system and disorders #110312 Nephrology and Urology
Tipo

Journal Article