Proposed modifications to metabolic model for glycogen-accumulating organisms under anaerobic conditions


Autoria(s): Zeng, R.; Yuan, Z.; van Loosdrecht, M. C. M.; Keller, J.
Data(s)

01/01/2002

Resumo

Filipe et al. (2001) proposed an anaerobic metabolic model for glycogen-accumulating organisms (GAO) in which the succinate-propionate pathway was used to describe the production of propionyl-CoA. However, propionyl-CoA is only an intermediate product in the above pathway. Stopping at propionyl-CoA instead of propionate (the end product of the pathway) results in the consumption of one ATP from succinate to succinyl-CoA, which was not accounted for in the model of Filipe et al. (2001). This resulted in significant errors in the stoichiometric coefficients in the final metabolic model. A modified model is presented in this communication and is shown to fit the experimental data significantly better than the original model. (C) 2002 Wiley Periodicals, Inc.

Identificador

http://espace.library.uq.edu.au/view/UQ:61549

Idioma(s)

eng

Publicador

John Wiley & Sons Inc

Palavras-Chave #Glycogen Accumulating Organisms (gao) #Metabolic Model #Succinate-propionate Pathway #Atp #Biotechnology & Applied Microbiology #Acetate Uptake #C1
Tipo

Journal Article