Proposed modifications to metabolic model for glycogen-accumulating organisms under anaerobic conditions
Data(s) |
01/01/2002
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Resumo |
Filipe et al. (2001) proposed an anaerobic metabolic model for glycogen-accumulating organisms (GAO) in which the succinate-propionate pathway was used to describe the production of propionyl-CoA. However, propionyl-CoA is only an intermediate product in the above pathway. Stopping at propionyl-CoA instead of propionate (the end product of the pathway) results in the consumption of one ATP from succinate to succinyl-CoA, which was not accounted for in the model of Filipe et al. (2001). This resulted in significant errors in the stoichiometric coefficients in the final metabolic model. A modified model is presented in this communication and is shown to fit the experimental data significantly better than the original model. (C) 2002 Wiley Periodicals, Inc. |
Identificador | |
Idioma(s) |
eng |
Publicador |
John Wiley & Sons Inc |
Palavras-Chave | #Glycogen Accumulating Organisms (gao) #Metabolic Model #Succinate-propionate Pathway #Atp #Biotechnology & Applied Microbiology #Acetate Uptake #C1 |
Tipo |
Journal Article |