Functional mapping of the periaqueductal gray matter involved in organizing tonic immobility behavior in guinea pigs


Autoria(s): VIEIRA, Eveline Bis; MENESCAL-DE-OLIVEIRA, Leda; LEITE-PANISSI, Christie Ramos Andrade
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2011

Resumo

Tonic immobility behavior (TI) is an innate response characterized by profound motor inhibition that is exhibited by prey when physical contact with a predator is prolonged and the situation inescapable. The periaqueductal gray matter (PAG) is intimately associated with the somatic and autonomic components of defensive reactions. This study investigated whether the TI response was able to recruit specific functional columns of the PAG by examining c-fos immunolocalization in guinea pigs. In the TI group, the innate response was invoked in animals through inversion and physical contention for at least 15 min. In the control group, the animals were physically manipulated only. Our results demonstrate that the defensive behavior of TI is capable of promoting the expression of Fos protein in different areas of the PAG, with higher levels of staining in the ventrolateral (vI) and lateral (I) columns. In addition, our results demonstrate increased Fos immunoreactivity (FOS-IR) in the dorsal raphe nucleus, the Edinger-Westphal nucleus, the cuneiform nucleus and the superior colliculus. In contrast, there were no significant alterations in the number of FOS-IR cells in the inferior colliculus or the oculomotor nucleus. Analysis of the results suggests that neuronal activation after the TI response differs by functional column of the PAG. (C) 2010 Elsevier B.V. All rights reserved.

FAPESP[JCN 09/52920-0]

CNPq[RAPG 202127/2006-0]

CNPq[MMZ 200166/2006-9]

Identificador

BEHAVIOURAL BRAIN RESEARCH, v.216, n.1, p.94-99, 2011

0166-4328

http://producao.usp.br/handle/BDPI/26202

10.1016/j.bbr.2010.07.013

http://dx.doi.org/10.1016/j.bbr.2010.07.013

Idioma(s)

eng

Publicador

ELSEVIER SCIENCE BV

Relação

Behavioural Brain Research

Direitos

restrictedAccess

Copyright ELSEVIER SCIENCE BV

Palavras-Chave #Defensive behavior #Tonic immobility #Periaqueductal gray matter #c-fos #Guinea pigs #DORSAL RAPHE NUCLEUS #EDINGER-WESTPHAL NUCLEUS #AMINO-ACID MICROINJECTION #FOS-LIKE IMMUNOREACTIVITY #DEFENSIVE BEHAVIOR #INFERIOR COLLICULUS #SUPERIOR COLLICULUS #STRESSOR CONTROLLABILITY #ELECTRICAL-STIMULATION #CHEMICAL-STIMULATION #Behavioral Sciences #Neurosciences
Tipo

article

original article

publishedVersion