Biological monitoring of a xenomaterial for grafting: an evaluation in critical-size calvarial defects
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
19/10/2012
19/10/2012
2011
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| Resumo |
Our purpose was to evaluate the osteoconduction potential of mixed bovine bone (MBB) xenografts as an alternative for bone grafting of critical-size defects in the calvaria of rats. After surgery, in the time intervals of 1, 3, 6, and 9 months, rats were killed and their skulls collected, radiographed and histologically prepared for analysis. The data obtained from histological analysis reported that the particles of MBB did not promote an intense immunological response, evidencing its biocompatibility in rats. Our results clearly showed the interesting evidence that MBB was not completely reabsorbed at 9 months while a small amount of newly formed bone was deposited by osteoprogenitor cells bordering the defect. However, this discrete bone-forming stimulation was unable to regenerate the bone defect. Overall, our results suggest that the properties of MBB are not suitable for stimulating intense bone regeneration in critical bone defects in rats. CAPES (CAPES Foundation) FAPESP (The State of Sao Paulo Research Foundation)[99/10655-5] FAPESP (The State of Sao Paulo Research Foundation)[01/10707-7] FAPESP (The State of Sao Paulo Research Foundation)[04/08095-1] CNPq (National Council for Scientific and Technological Development)[350084/03-3] CNPq (National Council for Scientific and Technological Development)[475721/2003-9] CNPq (National Council for Scientific and Technological Development)[505350/04-1] CNPq (National Council for Scientific and Technological Development)[504.808/04-4] |
| Identificador |
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v.22, n.4, p.997-1004, 2011 0957-4530 http://producao.usp.br/handle/BDPI/25906 10.1007/s10856-011-4278-7 |
| Idioma(s) |
eng |
| Publicador |
SPRINGER |
| Relação |
Journal of Materials Science-materials in Medicine |
| Direitos |
restrictedAccess Copyright SPRINGER |
| Palavras-Chave | #MONOCYTES IN-VITRO #BOVINE BONE #HYDROXYAPATITE PARTICLES #OSTEOBLAST ADHESION #MODEL #IMPLANTATION #SUBSTITUTE #MEMBRANES #PROTEIN #SURFACE #Engineering, Biomedical #Materials Science, Biomaterials |
| Tipo |
article original article publishedVersion |
