Gels Containing MMP Inhibitors Prevent Dental Erosion in situ
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
19/10/2012
19/10/2012
2010
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Resumo |
Matrix metalloproteinase (MMP) inhibition has been shown to reduce dentin caries progression, but its role in dental erosion has not yet been assessed. This study tested the hypothesis that gels containing MMP inhibitors (epigallocatechin gallate-EGCG and chlorhexidine) can prevent dental erosion. Volunteers (n = 10) wore palatal devices containing bovine dentin blocks (n = 10/group) treated for 1 min with EGCG at 10 (EGCG10) or 400 mu M (EGCG400), chlorhexidine at 0.012%, F at 1.23% (NaF), and no vehicle (placebo). Erosion was performed with Coca-Cola (R) (5 min) 4X/day during 5 days. The wear, assessed by profilometry (mean +/- SD, mu m), was significantly reduced by the gels containing MMP inhibitors (0.05 +/- 0.02(a), 0.04 +/- 0.02(a), and 0.05 +/- 0.02(a) for EGCG10, EGCG400, and chlorhexidine, respectively) when compared with NaF (0.79 +/- 0.35(b)) and placebo gels (1.77 +/- 0.35(b)) (Friedman and Dunn`s tests, p < 0.01). The use of gels delivering MMP inhibitors was shown to prevent erosion and opens a new perspective for protection against dental erosion. FAPESP[07/08389-3] FAPESP[07/04209-0] |
Identificador |
JOURNAL OF DENTAL RESEARCH, v.89, n.5, p.468-472, 2010 0022-0345 http://producao.usp.br/handle/BDPI/25840 10.1177/0022034510363248 |
Idioma(s) |
eng |
Publicador |
SAGE PUBLICATIONS INC |
Relação |
Journal of Dental Research |
Direitos |
closedAccess Copyright SAGE PUBLICATIONS INC |
Palavras-Chave | #dentin #chlorhexidine #epigallocatechin gallate #MMP #dental erosion #MATRIX METALLOPROTEINASES #ORGANIC MATRIX #GREEN TEA #VITRO #VIVO #CHLORHEXIDINE #ABRASION #ENAMEL #DEMINERALIZATION #COLLAGENASE #Dentistry, Oral Surgery & Medicine |
Tipo |
article original article publishedVersion |