Gels Containing MMP Inhibitors Prevent Dental Erosion in situ


Autoria(s): KATO, M. T.; LEITE, A. L.; HANNAS, A. R.; BUZALAF, M. A. R.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2010

Resumo

Matrix metalloproteinase (MMP) inhibition has been shown to reduce dentin caries progression, but its role in dental erosion has not yet been assessed. This study tested the hypothesis that gels containing MMP inhibitors (epigallocatechin gallate-EGCG and chlorhexidine) can prevent dental erosion. Volunteers (n = 10) wore palatal devices containing bovine dentin blocks (n = 10/group) treated for 1 min with EGCG at 10 (EGCG10) or 400 mu M (EGCG400), chlorhexidine at 0.012%, F at 1.23% (NaF), and no vehicle (placebo). Erosion was performed with Coca-Cola (R) (5 min) 4X/day during 5 days. The wear, assessed by profilometry (mean +/- SD, mu m), was significantly reduced by the gels containing MMP inhibitors (0.05 +/- 0.02(a), 0.04 +/- 0.02(a), and 0.05 +/- 0.02(a) for EGCG10, EGCG400, and chlorhexidine, respectively) when compared with NaF (0.79 +/- 0.35(b)) and placebo gels (1.77 +/- 0.35(b)) (Friedman and Dunn`s tests, p < 0.01). The use of gels delivering MMP inhibitors was shown to prevent erosion and opens a new perspective for protection against dental erosion.

FAPESP[07/08389-3]

FAPESP[07/04209-0]

Identificador

JOURNAL OF DENTAL RESEARCH, v.89, n.5, p.468-472, 2010

0022-0345

http://producao.usp.br/handle/BDPI/25840

10.1177/0022034510363248

http://dx.doi.org/10.1177/0022034510363248

Idioma(s)

eng

Publicador

SAGE PUBLICATIONS INC

Relação

Journal of Dental Research

Direitos

closedAccess

Copyright SAGE PUBLICATIONS INC

Palavras-Chave #dentin #chlorhexidine #epigallocatechin gallate #MMP #dental erosion #MATRIX METALLOPROTEINASES #ORGANIC MATRIX #GREEN TEA #VITRO #VIVO #CHLORHEXIDINE #ABRASION #ENAMEL #DEMINERALIZATION #COLLAGENASE #Dentistry, Oral Surgery & Medicine
Tipo

article

original article

publishedVersion