Specific infiltration of langerin-positive dendritic cells in EBV-infected tonsil, Hodgkin lymphoma and nasopharyngeal carcinoma
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
19/10/2012
19/10/2012
2011
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| Resumo |
We report here the existence of a novel subset of langerin (CD207)-positive, immature dendritic cells (DCs) (CD83(neg)) abundantly infiltrating Epstein Barr virus (EBV)-infected areas in tonsil, Hodgkin lymphoma and nasopharyngeal carcinoma. These CD207(+) DCs differ from conventional epidermal Langerhans cells in their lack of CD1a and CCR6 and their unusual tissue localization. CD207(+) DC infiltration strongly correlates with EBV infection because it was neither detected in EBV negative specimens nor in tissues infected with other human viruses. These immature DCs might represent good candidates for induction of the EBV-specific immune response. Institut National Contre le Cancer[PL0079] Sidaction[R08068AA] CAPES (Brazil) |
| Identificador |
INTERNATIONAL JOURNAL OF CANCER, v.128, n.10, p.2501-2508, 2011 0020-7136 http://producao.usp.br/handle/BDPI/25825 10.1002/ijc.25597 |
| Idioma(s) |
eng |
| Publicador |
WILEY-BLACKWELL |
| Relação |
International Journal of Cancer |
| Direitos |
restrictedAccess Copyright WILEY-BLACKWELL |
| Palavras-Chave | #EBV infection #dendritic cell infiltration #langerin/CD207 #EBV-associated tumors #EBV immune response #EPSTEIN-BARR-VIRUS #T-CELLS #MIGRATION #CCL20 #SKIN #Oncology |
| Tipo |
article original article publishedVersion |
