CASPASE EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMA
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
19/10/2012
19/10/2012
2011
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| Resumo |
Background. Apoptosis is a genetically programmed form of cell death, of which caspases are the central components. Methods. By tissue microarray of 229 cases of oral squamous cell carcinoma (OSCC), we analyzed the immunoexpression of caspases 3, 6, 7, 8, 9, and 10. Results. All proteins that we examined were expressed in primary OSCC samples. Caspases 8 and 9 were prominently expressed, and caspases 3, 6, 7, and 10 were occasionally expressed. Disease-free survival differed significantly between caspase 7 high-expressing and low-expressing patients, and our multivariate analysis suggested that expression of caspase 7 is an independent prognostic factor for patients with OSCC. Conclusion. This study suggests that caspases regulate the tumorigenesis of OSCC and that caspase 7 expression is a predictor of locoregional recurrence of OSCC. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 1191-1198, 2011 FAPESP[98/14335-2] FAPESP[07/50608-4] |
| Identificador |
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, v.33, n.8, p.1191-1198, 2011 1043-3074 http://producao.usp.br/handle/BDPI/25716 10.1002/hed.21602 |
| Idioma(s) |
eng |
| Publicador |
WILEY-BLACKWELL |
| Relação |
Head and Neck-journal for the Sciences and Specialties of the Head and Neck |
| Direitos |
restrictedAccess Copyright WILEY-BLACKWELL |
| Palavras-Chave | #caspases #oral squamous cell carcinoma #tissue microarray #immunohistochemistry #apoptosis #LUNG-CANCER #APOPTOSIS #POLYMORPHISMS #TONGUE #GENES #BCL-2 #RISK #P53 #Otorhinolaryngology #Surgery |
| Tipo |
article original article publishedVersion |
