Dual origin of mesenchymal stem cells contributing to organ growth and repair


Autoria(s): FENG, Jifan; MANTESSO, Andrea; BARI, Cosimo De; NISHIYAMA, Akiko; SHARPE, Paul T.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2011

Resumo

In many adult tissues, mesenchymal stem cells (MSCs) are closely associated with perivascular niches and coexpress many markers in common with pericytes. The ability of pericytes to act as MSCs, however, remains controversial. By using genetic lineage tracing, we show that some pericytes differentiate into specialized tooth mesenchyme-derived cells-odontoblasts-during tooth growth and in response to damage in vivo. As the pericyte-derived mesenchymal cell contribution to odontoblast differentiation does not account for all cell differentiation, we identify an additional source of cells with MSC-like properties that are stimulated to migrate toward areas of tissue damage and differentiate into odontoblasts. Thus, although pericytes are capable of acting as a source of MSCs and differentiating into cells of mesenchymal origin, they do so alongside other MSCs of a nonpericyte origin. This study identifies a dual origin of MSCs in a single tissue and suggests that the pericyte contribution to MSC-derived mesenchymal cells in any given tissue is variable and possibly dependent on the extent of the vascularity.

MRC[G0600041]

Identificador

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.108, n.16, p.6503-6508, 2011

0027-8424

http://producao.usp.br/handle/BDPI/25660

10.1073/pnas.1015449108

http://dx.doi.org/10.1073/pnas.1015449108

Idioma(s)

eng

Publicador

NATL ACAD SCIENCES

Relação

Proceedings of the National Academy of Sciences of the United States of America

Direitos

restrictedAccess

Copyright NATL ACAD SCIENCES

Palavras-Chave #dental pulp #tooth development #dental stem cells #HUMAN ARTICULAR CHONDROCYTES #BONE-MARROW #DENTAL-PULP #SMOOTH-MUSCLE #ADIPOSE-TISSUE #NG2 CELLS #IN-VIVO #GENE #PRECURSORS #EXPRESSION #Multidisciplinary Sciences
Tipo

article

original article

publishedVersion