The immunohistochemical profile of oral inflammatory myofibroblastic tumors


Autoria(s): SALGUEIREDO-GIUDICE, Fernanda; FORNIAS-SPERANDIO, Felipe; MARTINS-PEREIRA, Erika; VECHIO, Aluana Maria da Costa dal; SOUSA, Suzana Cantanhede Orsini Machado de; SANTOS-PINTO-JUNIOR, Decio dos
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2011

Resumo

Objective. The aim of this study was to demonstrate the immunohistochemical profile of oral inflammatory myofibroblastic tumors (IMTs) along with morphologic analysis. Study design. Three cases diagnosed as oral IMTs were selected to compile an immunohistochemical panel constituted by calponin, caldesmon, Bcl-2, desmin, fibronectin, CD68, Ki-67, S100, anaplastic lymphoma kinase (ALK), alpha-smooth muscle actin, cytokeratins AE1/AE3, muscle-specific actin, CD34, and vimentin. An oral squamous cell carcinoma with a focal area of desmoplastic stroma was used as control for the stained myofibroblastic cells. Results. All oral IMTs were positive for calponin, revealing a strong and diffuse expression in the spindle-shaped cells. The lesions were also positive for vimentin (3/3), fibronectin (3/3), alpha-smooth muscle actin (3/3), and muscle-specific actin (1/3) and negative for h-caldesmon, Bcl-2, desmin, CD68, Ki-67, S100, ALK, cytokeratins AE1/AE3, and CD34. Conclusions. Within the results encountered, the present panel should be of great assistance in the diagnosis of oral IMTs. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011; 111: 749-756)

Identificador

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, v.111, n.6, p.749-756, 2011

1079-2104

http://producao.usp.br/handle/BDPI/25657

10.1016/j.tripleo.2010.12.023

http://dx.doi.org/10.1016/j.tripleo.2010.12.023

Idioma(s)

eng

Publicador

MOSBY-ELSEVIER

Relação

Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology

Direitos

restrictedAccess

Copyright MOSBY-ELSEVIER

Palavras-Chave #SOLITARY FIBROUS TUMOR #ROSAI-DORFMAN DISEASE #SOFT-TISSUE TUMORS #OF-THE-LITERATURE #H-CALDESMON #DIFFERENTIAL-DIAGNOSIS #CELL TUMOR #PSEUDOTUMOR #EXPRESSION #CALPONIN #Dentistry, Oral Surgery & Medicine
Tipo

article

original article

publishedVersion