The immunohistochemical profile of oral inflammatory myofibroblastic tumors
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
19/10/2012
19/10/2012
2011
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Resumo |
Objective. The aim of this study was to demonstrate the immunohistochemical profile of oral inflammatory myofibroblastic tumors (IMTs) along with morphologic analysis. Study design. Three cases diagnosed as oral IMTs were selected to compile an immunohistochemical panel constituted by calponin, caldesmon, Bcl-2, desmin, fibronectin, CD68, Ki-67, S100, anaplastic lymphoma kinase (ALK), alpha-smooth muscle actin, cytokeratins AE1/AE3, muscle-specific actin, CD34, and vimentin. An oral squamous cell carcinoma with a focal area of desmoplastic stroma was used as control for the stained myofibroblastic cells. Results. All oral IMTs were positive for calponin, revealing a strong and diffuse expression in the spindle-shaped cells. The lesions were also positive for vimentin (3/3), fibronectin (3/3), alpha-smooth muscle actin (3/3), and muscle-specific actin (1/3) and negative for h-caldesmon, Bcl-2, desmin, CD68, Ki-67, S100, ALK, cytokeratins AE1/AE3, and CD34. Conclusions. Within the results encountered, the present panel should be of great assistance in the diagnosis of oral IMTs. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011; 111: 749-756) |
Identificador |
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, v.111, n.6, p.749-756, 2011 1079-2104 http://producao.usp.br/handle/BDPI/25657 10.1016/j.tripleo.2010.12.023 |
Idioma(s) |
eng |
Publicador |
MOSBY-ELSEVIER |
Relação |
Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology |
Direitos |
restrictedAccess Copyright MOSBY-ELSEVIER |
Palavras-Chave | #SOLITARY FIBROUS TUMOR #ROSAI-DORFMAN DISEASE #SOFT-TISSUE TUMORS #OF-THE-LITERATURE #H-CALDESMON #DIFFERENTIAL-DIAGNOSIS #CELL TUMOR #PSEUDOTUMOR #EXPRESSION #CALPONIN #Dentistry, Oral Surgery & Medicine |
Tipo |
article original article publishedVersion |