High-pressure phase diagram of the drug mitotane in compressed and/or supercritical CO(2)
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
19/10/2012
19/10/2012
2010
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| Resumo |
This work provides experimental phase diagram of mitotane, a drug used in the chemotherapy treatment of adrenocortical carcinoma, in compressed and/or supercritical CO(2). The synthetic-static method in a high-pressure variable-volume view cell coupled with a transmitted-light intensity probe was used to measure the solid-fluid (SF) equilibrium data. The phase equilibrium experiments were determined in temperature ranging from (298.2 to 333.1) K and pressure up to 22 MPa. Peng-Robinson equation of state (PR-EoS) with classical mixing rule was used to correlate the experimental data. Excellent agreement was found between experimental and calculated values. (C) 2009 Elsevier Ltd. All rights reserved. FAPESP CNPq CAPES |
| Identificador |
The Journal of Chemical Thermodynamics, v.42, n.2, p.286-290, 2010 0021-9614 http://producao.usp.br/handle/BDPI/25450 10.1016/j.jct.2009.08.017 |
| Idioma(s) |
eng |
| Publicador |
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
| Relação |
The Journal of Chemical Thermodynamics |
| Direitos |
restrictedAccess Copyright ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
| Palavras-Chave | #Transmitted-light intensity #Mitotane #CO(2) #Cubic equation of state #HEAVY AROMATIC-HYDROCARBONS #MOVING-BED CHROMATOGRAPHY #CARBON-DIOXIDE #SOLID SOLUBILITIES #NAPHTHALENE #ISOMERS #MIXTURES #SYSTEMS #FLUIDS #Thermodynamics #Chemistry, Physical |
| Tipo |
article original article publishedVersion |
