Liver iron overloading in captive muriquis (Brachyteles spp.)

Background Iron accumulation was investigated qualitatively and quantitatively in the liver of 15 captive Brachyteles spp. Methods Hepatic hemosiderosis index (HHI) was determined as the area percentage of the liver parenchyma occupied by hemosiderin and ferritin deposits, through computerized histomorphometric analysis of Prussian blue-stained histologic sections. Results All studied animals presented liver hemosiderosis, and HHI ranged from 0.2% to 41.7%. There were no significant differences in HHI between muriqui species or genders, and no correlations were detected among HHI and age, time in captivity or body mass. Iron deposits were accompanied by other hepatic disorders. Conclusions This is the first study addressing the occurrence and consequences of iron overloading in the liver of muriquis. We propose that hemosiderosis may act as a contribute factor for the development of hepatic injuries. Further studies are advised to clarify the role of diet in the pathogenesis of hemosiderosis in these atelids.

FAPESP

CPRJ-INEA

IBAMA

FAPERJ

FINEP

Greater Los Angeles Zoo Association (GLAZA)

The Zoological Society of Philadelphia

American Society of Primatologist (ASP)

Conservation International (CI)

Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)

Conselho Nacional de Desenvolvimento Cientifico e Tecnologico[CNPq 301517-2006-1]