Complete genome analysis of a rabies virus isolate from Brazilian wild fox
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
19/10/2012
19/10/2012
2009
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Resumo |
The complete genome sequence of wild-type rabies virus (RABV) isolated from a wild Brazilian hoary fox (Dusicyon sp.), the BR-Pfx1 isolate, was determined and compared with fixed RABV strains. The genome structure and organization of the BR-Pfx1 isolate were composed of 11,924 nt and included the five standard genes of rhabdoviruses. Sequences of mRNA start and stop signals for transcription were highly conserved among all structural protein genes of the BR-Pfx1 isolate. All amino acid residues in the glycoprotein (G) gene associated with pathogenicity were retained in the BR-Pfx1 isolate, while unique amino acid substitutions were found in antigenic region I of the nucleoprotein gene and III of G. These results suggest that although the standard genome structure and organization of the RABV isolate are common between the BR-Pfx1 isolate and fixed RABV strains, the unique amino acid substitutions in functional sites of the BR-Pfx1 isolate may result in different biological characteristics from fixed RABV strains. Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan Re-emerging Infectious Diseases, Ministry of Health, Labour and Welfare, Japan |
Identificador |
ARCHIVES OF VIROLOGY, v.154, n.9, p.1475-1488, 2009 0304-8608 http://producao.usp.br/handle/BDPI/25347 10.1007/s00705-009-0475-9 |
Idioma(s) |
eng |
Publicador |
SPRINGER WIEN |
Relação |
Archives of Virology |
Direitos |
restrictedAccess Copyright SPRINGER WIEN |
Palavras-Chave | #VESICULAR STOMATITIS-VIRUS #MATRIX PROTEIN GENES #STRAND RNA VIRUSES #DYNEIN LIGHT-CHAIN #HEP-FLURY STRAIN #NORTHEASTERN BRAZIL #ANTIGENIC SITES #ADULT MICE #MOLECULAR CHARACTERIZATION #NUCLEOTIDE-SEQUENCE #Virology |
Tipo |
article original article publishedVersion |