Polymorphisms of xenobiotic metabolizing enzymes and DNA repair genes and outcome in childhood acute lymphoblastic leukemia


Autoria(s): SILVEIRA, Vanessa da Silva; CANALLE, Renata; SCRIDELI, Carlos Alberto; QUEIROZ, Rosane Gomes de Paula; BETTIOL, Heloisa; VALERA, Elvis Terci; TONE, Luiz Gonzaga
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2009

Resumo

The interindividual variation in the activity of xenobiotic metabolizing enzymes and DNA repair genes could modify an individual`s risk of recurrent malignancy and response to therapy. We investigated whether ALL outcome was related to polymorphisms in genes CYP2D6. MPO, EPHX1, NQO1, TS, XPD and XRCC1 in 95 consecutive ALL children by PCR or PCR-FRLP techniques. Polymorphisms in genes NQO1 and TS were associated with a significantly slow response to induction chemotherapy and NQO1 was also associated with a lower five-year event-free survival. This study suggests that polymorphisms of NQO1 and TS could be important for patient response to induction therapy and for treatment outcome. (C) 2009 Elsevier Ltd. All rights reserved.

Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)[150163/2004-5]

Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)[03/02527-4]

Identificador

LEUKEMIA RESEARCH, v.33, n.7, p.898-901, 2009

0145-2126

http://producao.usp.br/handle/BDPI/24820

10.1016/j.leukres.2008.12.006

http://dx.doi.org/10.1016/j.leukres.2008.12.006

Idioma(s)

eng

Publicador

PERGAMON-ELSEVIER SCIENCE LTD

Relação

Leukemia Research

Direitos

closedAccess

Copyright PERGAMON-ELSEVIER SCIENCE LTD

Palavras-Chave #Genetic polymorphisms #Childhood ALL #Xenobiotic metabolizing enzymes #DNA repair genes and treatment outcome #THYMIDYLATE SYNTHASE GENE #ACUTE MYELOID-LEUKEMIA #CANCER #RISK #SUSCEPTIBILITY #CHEMOTHERAPY #CHILDREN #Oncology #Hematology
Tipo

article

original article

publishedVersion