Polymorphisms of xenobiotic metabolizing enzymes and DNA repair genes and outcome in childhood acute lymphoblastic leukemia
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
19/10/2012
19/10/2012
2009
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Resumo |
The interindividual variation in the activity of xenobiotic metabolizing enzymes and DNA repair genes could modify an individual`s risk of recurrent malignancy and response to therapy. We investigated whether ALL outcome was related to polymorphisms in genes CYP2D6. MPO, EPHX1, NQO1, TS, XPD and XRCC1 in 95 consecutive ALL children by PCR or PCR-FRLP techniques. Polymorphisms in genes NQO1 and TS were associated with a significantly slow response to induction chemotherapy and NQO1 was also associated with a lower five-year event-free survival. This study suggests that polymorphisms of NQO1 and TS could be important for patient response to induction therapy and for treatment outcome. (C) 2009 Elsevier Ltd. All rights reserved. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)[150163/2004-5] Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)[03/02527-4] |
Identificador |
LEUKEMIA RESEARCH, v.33, n.7, p.898-901, 2009 0145-2126 http://producao.usp.br/handle/BDPI/24820 10.1016/j.leukres.2008.12.006 |
Idioma(s) |
eng |
Publicador |
PERGAMON-ELSEVIER SCIENCE LTD |
Relação |
Leukemia Research |
Direitos |
closedAccess Copyright PERGAMON-ELSEVIER SCIENCE LTD |
Palavras-Chave | #Genetic polymorphisms #Childhood ALL #Xenobiotic metabolizing enzymes #DNA repair genes and treatment outcome #THYMIDYLATE SYNTHASE GENE #ACUTE MYELOID-LEUKEMIA #CANCER #RISK #SUSCEPTIBILITY #CHEMOTHERAPY #CHILDREN #Oncology #Hematology |
Tipo |
article original article publishedVersion |