Escitalopram prolonged fear induced by simulated public speaking and released hypothalamic-pituitary-adrenal axis activation


Autoria(s): GARCIA-LEAL, C.; DEL-BEN, C. M.; LEAL, F. M.; GRAEFF, F. G.; GUIMARAES, F. S.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2010

Resumo

Simulated public speaking (SPS) test is sensitive to drugs that interfere with serotonin-mediated neurotransmission and is supposed to recruit neural systems involved in panic disorder. The study was aimed at evaluating the effects of escitalopram, the most selective serotonin-selective reuptake inhibitor available, in SPS. Healthy males received, in a double-blind, randomized design, placebo (n = 12), 10 (n = 17) or 20 (n = 14) mg of escitalopram 2 hours before the test. Behavioural, autonomic and neuroendocrine measures were assessed. Both doses of escitalopram did not produce any effect before or during the speech but prolonged the fear induced by SPS. The test itself did not significantly change cortisol and prolactin levels but under the higher dose of escitalopram, cortisol and prolactin increased immediately after SPS. This fear-enhancing effect of escitalopram agrees with previously reported results with less selective serotonin reuptake inhibitors and the receptor antagonist ritanserin, indicating that serotonin inhibits the fear of speaking in public.

Identificador

JOURNAL OF PSYCHOPHARMACOLOGY, v.24, n.5, p.683-694, 2010

0269-8811

http://producao.usp.br/handle/BDPI/24628

10.1177/0269881108101782

http://dx.doi.org/10.1177/0269881108101782

Idioma(s)

eng

Publicador

SAGE PUBLICATIONS LTD

Relação

Journal of Psychopharmacology

Direitos

restrictedAccess

Copyright SAGE PUBLICATIONS LTD

Palavras-Chave #anxiety #human experimental anxiety #panic #serotonin #stress hormones #SEROTONIN REUPTAKE INHIBITOR #HUMAN EXPERIMENTAL ANXIETY #NEUROENDOCRINE CHALLENGE-TESTS #CITALOPRAM INCREASES FEAR #DORSAL RAPHE NUCLEUS #PANIC DISORDER #HEALTHY-VOLUNTEERS #PRIMARY-CARE #DOUBLE-BLIND #SALIVARY CORTISOL #Clinical Neurology #Neurosciences #Pharmacology & Pharmacy #Psychiatry
Tipo

article

original article

publishedVersion