Alterations in cyclic GMP levels in preeclampsia may reflect increased B-type natriuretic peptide levels and not impaired nitric oxide activity

Objectives: We compared nitrite, B-type natriuretic peptide (BNP), and cGMP levels in preeclamptic with those found in healthy pregnant. Methods: We studied 21 healthy pregnant and 27 preeclamptic. Plasma cGMP and BNP levels were determined by ELISA. Nitrite levels were determined by chemiluminescence. Results: Higher cGMP and BNP, and lower nitrite levels were found in preeclamptic versus healthy pregnant Conclusions: Altered cGMP levels reflect increased BNP levels and not impaired nitric oxide activity in preeclampsia. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP-Brazil)

Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG-Brazil)

Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq-Brazil)

Loreal-UNESCO-ABC ""For Women in Science""