Involvement of the lateral septal area in the expression of fear conditioning to context
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
19/10/2012
19/10/2012
2010
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| Resumo |
Considering the evidence that the lateral septal area (LSA) modulates defensive responses, the aim of the present study is to verify if this structure is also involved in contextual fear conditioning responses. Neurotransmission in the LSA was reversibly inhibited by bilateral microinjections of cobalt chloride (CoCl(2), 1 mM) 10 min before or after conditioning or 10 min before re-exposure to the aversively conditioned chamber. Only those animals that received CoCl(2) before re-exposure showed a decrease in both cardiovascular and behavioral conditioned responses. These results suggest that the LSA participates in the expression, but not acquisition or consolidation, of contextual fear conditioning. FAPESP[2008/04069-7] CAPES[PNPD0176087] CNPq[305996/2008-8] CNPq[480550/2007-7] FAEPA |
| Identificador |
LEARNING & MEMORY, v.17, n.3, p.134-138, 2010 1072-0502 http://producao.usp.br/handle/BDPI/24334 10.1101/lm.1534710 |
| Idioma(s) |
eng |
| Publicador |
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT |
| Relação |
Learning & Memory |
| Direitos |
restrictedAccess Copyright COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT |
| Palavras-Chave | #MEDIAL PREFRONTAL CORTEX #PROBE-BURYING TESTS #UNANESTHETIZED RATS #CARDIOVASCULAR-RESPONSES #REVERSIBLE INACTIVATION #HIPPOCAMPAL-FORMATION #DORSAL HIPPOCAMPUS #PRELIMBIC CORTEX #STRIA TERMINALIS #ACUTE RESTRAINT #Neurosciences #Psychology, Experimental |
| Tipo |
article original article publishedVersion |
