Antileishmanial activity of ruthenium(II)tetraammine nitrosyl complexes
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
19/10/2012
19/10/2012
2010
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Resumo |
The complexes trans-[Ru(NO)(NH(3))(4)L](X)(3) (X = BF(4)(-), PF(6)(-) or Cl(-) and L = N-heterocyclic ligands, P (OEt)(3), SO(3)(-2)), and [Ru(NO)Hedta)] were shown to exhibit IC(50pro) in the range of 36 (L = imN) to 5000 mu M (L = imC). The inhibitory effects of trans-[Ru(NO)(NH(3))(4)imN](BF(4))(3) and of the Angeli`s salt on the growth of the intramacrophage amastigote form studied were found to be similar while the trans-[Ru(NH(3))(4)imN(H(2)O)](2+) complex was found not to exhibit any substantial antiamastigote effect. The trans-[Ru(NO)(NH(3))(4)imN](BF(4))(3) compound, administered (500 nmol kg(-1) day(-1)) in BALB/c mice infected with Leishmania major, was found to exhibit a 98% inhibition on the parasite growth. Furthermore, this complex proved to be at least 66 times more efficient than glucantime in in vivo experiments. (C) 2010 Elsevier Masson SAS. All rights reserved. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)[06/53266-4] |
Identificador |
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.45, n.9, p.4180-4187, 2010 0223-5234 http://producao.usp.br/handle/BDPI/24314 10.1016/j.ejmech.2010.06.010 |
Idioma(s) |
eng |
Publicador |
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
Relação |
European Journal of Medicinal Chemistry |
Direitos |
restrictedAccess Copyright ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
Palavras-Chave | #Nitric oxide #Ruthenium complexes #Nitroxyl #Leishmania major #NITRIC-OXIDE DONOR #NITROXYL HNO #COORDINATION CHEMISTRY #NO DONORS #IN-VITRO #RUTHENIUM #LEISHMANIASIS #REACTIVITY #TOXICITY #CYSTEINE #Chemistry, Medicinal |
Tipo |
article original article publishedVersion |