Antileishmanial activity of ruthenium(II)tetraammine nitrosyl complexes


Autoria(s): PEREIRA, Jose Clayston Melo; CARREGARO, Vanessa; COSTA, Diego Luis; SILVA, Joao Santana da; CUNHA, Fernando Q.; FRANCO, Douglas Wagner
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2010

Resumo

The complexes trans-[Ru(NO)(NH(3))(4)L](X)(3) (X = BF(4)(-), PF(6)(-) or Cl(-) and L = N-heterocyclic ligands, P (OEt)(3), SO(3)(-2)), and [Ru(NO)Hedta)] were shown to exhibit IC(50pro) in the range of 36 (L = imN) to 5000 mu M (L = imC). The inhibitory effects of trans-[Ru(NO)(NH(3))(4)imN](BF(4))(3) and of the Angeli`s salt on the growth of the intramacrophage amastigote form studied were found to be similar while the trans-[Ru(NH(3))(4)imN(H(2)O)](2+) complex was found not to exhibit any substantial antiamastigote effect. The trans-[Ru(NO)(NH(3))(4)imN](BF(4))(3) compound, administered (500 nmol kg(-1) day(-1)) in BALB/c mice infected with Leishmania major, was found to exhibit a 98% inhibition on the parasite growth. Furthermore, this complex proved to be at least 66 times more efficient than glucantime in in vivo experiments. (C) 2010 Elsevier Masson SAS. All rights reserved.

Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)

Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)

Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)[06/53266-4]

Identificador

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.45, n.9, p.4180-4187, 2010

0223-5234

http://producao.usp.br/handle/BDPI/24314

10.1016/j.ejmech.2010.06.010

http://dx.doi.org/10.1016/j.ejmech.2010.06.010

Idioma(s)

eng

Publicador

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER

Relação

European Journal of Medicinal Chemistry

Direitos

restrictedAccess

Copyright ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER

Palavras-Chave #Nitric oxide #Ruthenium complexes #Nitroxyl #Leishmania major #NITRIC-OXIDE DONOR #NITROXYL HNO #COORDINATION CHEMISTRY #NO DONORS #IN-VITRO #RUTHENIUM #LEISHMANIASIS #REACTIVITY #TOXICITY #CYSTEINE #Chemistry, Medicinal
Tipo

article

original article

publishedVersion