Poly(ethylene glycol) decorated poly(methylmethacrylate) nanoparticles for protein adsorption
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
19/10/2012
19/10/2012
2011
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| Resumo |
Poly(ethylene glycol) decorated poly( methyl methacrylate) particles were synthesized by means of emulsion polymerization using poly(ethylene glycol) sorbitan monolaurate (Tween-20) as surfactant. PMMA/PEG particles presented mean diameter (195 +/- 15) nm, indicating narrow size distribution. The adsorption behavior of bovine serum albumin (BSA) and concanavalin A (ConA) onto PMMA/PEG particles was investigated by means of spectrophotometry. Adsorption isotherms obtained for BSA onto PMMA/PEG particles fitted well sigmoidal function, which is typical for multilayer adsorption. Con A adsorbed irreversibly onto PMMA/PEG particles. The efficiency of ConA covered particles to induce dengue virus quick agglutination was evaluated. (C) 2010 Elsevier B.V. All rights reserved. CNPq FAPESP |
| Identificador |
Materials science and engineering. C, Biomimetic materials, sensors and systems, v.31, n.3, p.562-566, 2011 0928-4931 http://producao.usp.br/handle/BDPI/24072 10.1016/j.msec.2010.11.020 |
| Idioma(s) |
eng |
| Publicador |
ELSEVIER SCIENCE BV |
| Relação |
Materials science and engineering. C, Biomimetic materials, sensors and systems |
| Direitos |
restrictedAccess Copyright ELSEVIER SCIENCE BV |
| Palavras-Chave | #Poly(ethylene)glycol #Nanoparticles #BSA #Concanavalin A #Dengue virus #Adsorption #BOVINE SERUM-ALBUMIN #CONCANAVALIN-A #CREATINE-PHOSPHOKINASE #THIN-FILMS #PARTICLES #BEHAVIOR #BINDING #PH #CARBOXYMETHYLCELLULOSE #SURFACES #Materials Science, Biomaterials |
| Tipo |
article original article publishedVersion |
