Effects of acute magnesium loading on pulmonary function of stable COPD patients


Autoria(s): AMARAL, Angelica Floripedes do; RODRIGUES-JUNIOR, Antonio Luiz; TERRA FILHO, Joao; VANNUCCHI, Helio; MARTINEZ, Jose Antonio Baddini
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2008

Resumo

Background: Magnesium (Mg) use has the potential to promote bronchodilatation and to improve lung function in obstructive diseases. IV administration of Mg during exacerbations of chronic obstructive pulmonary disease (COPD) has led to improved peak flow. This study aimed to investigate the effects of acute IV Mg loading on respiratory parameters of stable COPD patients. Material/Methods: This was a randomized, double-blind, placebo-controlled crossover study. Twenty-two male COPD patients (64 +/- 6 years old, FEV1: 49 +/- 20%) received an IV infusion of 2 g of magnesium sulfate or placebo on two distinct occasions. Spirometry and mouth maximal respiratory pressures were obtained before and 45 minutes after the infusions. Results: Mg use led to significant changes in functional respiratory capacity (-0.48 1,95% CI: -0.96, -0.01), inspiratory capacity (0.21 1,95% CI: 0.04, 0.37). The treatment was also associated with a marginally significant decrease in residual volume (-0.47 1,95% CI: -0.96, 0.02, p=0.06). Conclusions: Acute IV Mg loading in stable COPD patients was associated with a reduction in lung hyperinflation and improvement of respiratory muscle strength. The clinical potential for chronic magnesium supplementation in COPD deserves further investigation.

Research Brazilian Council-CNPq

Identificador

MEDICAL SCIENCE MONITOR, v.14, n.10, p.CR524-CR529, 2008

1234-1010

http://producao.usp.br/handle/BDPI/24026

http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000260873500013&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord

Idioma(s)

eng

Publicador

INT SCIENTIFIC LITERATURE, INC

Relação

Medical Science Monitor

Direitos

closedAccess

Copyright INT SCIENTIFIC LITERATURE, INC

Palavras-Chave #COPD #lung hyperinflation #magnesium #respiratory muscles #LUNG-FUNCTION #ACUTE ASTHMA #DIETARY MAGNESIUM #SULFATE #DISEASE #EXERCISE #MUSCLE #HYPERINFLATION #EXACERBATIONS #VALUES #Medicine, Research & Experimental
Tipo

article

original article

publishedVersion