Childhood radiation-associated atypical meningioma with novel complex rearrangements involving chromosomes 1 and 12


Autoria(s): BRASSESCO, Maria Sol; VALERA, Elvis Terci; NEDER, Luciano; CASTRO-GAMERO, Angel Mauricio; OLIVEIRA, Fabio Morato de; SANTOS, Antonio Carlos; SCRIDELI, Carlos Alberto; OLIVEIRA, Ricardo Santos; MACHADO, Helio Rubens; TONE, Luiz Gonzaga
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2009

Resumo

Meningiomas are recognized as the most common late complication following radiotherapy. However, cytogenetic studies in childhood atypical radiation-induced meningioma are sporadic, mainly because this condition generally occurs after a long latent period. In the present study we show the results of conventional and molecular cytogenetics in a 14-year-old boy with a secondary atypical meningioma. Apart from numerical changes, we found complex aberrations with the participation of chromosomes 1, 6 and 12. The invariable presence of loss of 1p was demonstrated by fluorescent in situ hybridization (FISH) analysis with probes directed to telomeric regions and by comparative genome hybridization (CGH). Previous cytogenetic studies on adult spontaneous and radiation-associated meningiomas showed loss of chromosome 22 as the most frequent change, followed by loss of the short arm of chromosome 1. To the best of our knowledge this is the first report of highly complex chromosome aberrations in the pediatric setting of meningioma.

FAPESP Fundacao de Amparo Pesquisa do Estado de Sao Paulo[07/54236-4]

FAPESP Fundacao de Amparo Pesquisa do Estado de Sao Paulo[06/04827-3]

Identificador

NEUROPATHOLOGY, v.29, n.5, p.585-590, 2009

0919-6544

http://producao.usp.br/handle/BDPI/23887

10.1111/j.1440-1789.2008.00991.x

http://dx.doi.org/10.1111/j.1440-1789.2008.00991.x

Idioma(s)

eng

Publicador

WILEY-BLACKWELL PUBLISHING, INC

Relação

Neuropathology

Direitos

restrictedAccess

Copyright WILEY-BLACKWELL PUBLISHING, INC

Palavras-Chave #children #chromosomes 1 and 12 #complex rearrangements #radiation-induced meningioma #DOSE CRANIAL IRRADIATION #IN-SITU HYBRIDIZATION #OF-THE-LITERATURE #INTRACRANIAL MENINGIOMAS #MALIGNANT PROGRESSION #TUMOR PROGRESSION #DELETION #IDENTIFICATION #CHILDREN #Clinical Neurology #Neurosciences #Pathology
Tipo

article

original article

publishedVersion