Dissemination of bla(KPC-2) by the Spread of Klebsiella pneumoniae Clonal Complex 258 Clones (ST258, ST11, ST437) and Plasmids (IncFII, IncN, IncL/M) among Enterobacteriaceae Species in Brazil

This article reports the spread of bla(KPC-2) in the Sao Paulo and Rio de Janeiro states, facilitated by globally spread K. pneumoniae clonal complex 258 (CC258) clones (ST258, ST11, and ST437) and a diversity of plasmids (IncFII, IncN, and IncL/M, two untypeable plasmids carrying Tn4401a or Tn4401b) successfully disseminated among species of the Enterobacteriaceae (Enterobacter cloacae, Serratia marcescens, and Citrobacter freundii). It also constitutes the first description of sequence type 258 (ST258) in Brazil, which was associated with a nosocomial hospital outbreak in Ribeirao Preto city.

Conselho Nacional de Desenvolvimento Cientifico e Tecnologico in Brazil (CNPq)[480848/2008-4]

Conselho Nacional de Desenvolvimento Cientifico e Tecnologico in Brazil (CNPq)[142736/2008-2]

Conselho Nacional de Desenvolvimento Cientifico e Tecnologico in Brazil (CNPq)[201191/2009-1]

European Commission[LSHM-CT-2009-227258 HEALTH-F3-2008-223031]

CIBERESP Network for Biomedical Research in Epidemiology and Public Health (Instituto Carlos III, Ministerio de Ciencia e Innovacion of Spain)[CB06/02/0053]

Instituto Carlos III, Spanish Ministry of Science and Innovation[FI09/00901]