Sudden unexpected death in an adolescent with epilepsy: All roads lead to the heart?


Autoria(s): PINTO, Kylvia G. F. D.; SCORZA, Fulvio A.; ARIDA, Ricardo M.; CAVALHEIRO, Esper A.; MARTINS, Luciana D.; MACHADO, Helio R.; SAKAMOTO, Americo C.; TERRA, Vera C.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2011

Resumo

The incidence of sudden unexpected death in epilepsy (SUDEP) has been estimated from 0.5-1.4/1,000 person-years in people with treated epilepsy, and 9/1,000 person-years in candidates for epilepsy surgery. Potential risk factors for SUDEP include: age, early onset of epilepsy, duration of epilepsy, uncontrolled seizures, seizure type and winter temperatures. The arrythmogenic side-effect of antiepileptic drugs and seizures may increase the risk of SUDEP. In this report, we describe a patient with prolonged post-ictal tachycardia in EEG video recordings with a typical case of SUDEP: a 16-year-old boy with medically intractable complex partial seizures. Magnetic resonance imaging revealed left mesial temporal sclerosis. During non-invasive video-EEG monitoring, the patient presented a post-ictal heart rate increased for five hours. Two months after video-EEG, he died from SUDEP during a tonic-clonic secondary generalized seizure. The possibility of cardiac involvement in the pathogenesis of SUDEP has been suggested by many studies. Evaluation of this patient with EEG-video monitoring, including measurement of heart rate, contributed to an identification of ictal tachycardia that may have played a role in the SUDEP. Premature mortality seems to be increased in patients with epilepsy, and cardiac abnormalities may be a possible cause of SUDEP. (Cardiol J 2011; 18, 2: 194-196)

FAPESP

CInAPCe-FAPESP

INCT/MCT

CNPq

Identificador

CARDIOLOGY JOURNAL, v.18, n.2, p.194-196, 2011

1897-5593

http://producao.usp.br/handle/BDPI/23853

http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000293941000014&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord

Idioma(s)

eng

Publicador

VIA MEDICA

Relação

Cardiology Journal

Direitos

restrictedAccess

Copyright VIA MEDICA

Palavras-Chave #sudden death #epilepsy #EEG #heart #Cardiac & Cardiovascular Systems
Tipo

article

original article

publishedVersion