Gastrointestinal stromal tumor in Brazil: Clinicopathology, immunohistochemistry, and molecular genetics of 513 cases


Autoria(s): LOPES, Lisandro Ferreira; OJOPI, Elida B.; BACCHI, Carlos E.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2008

Resumo

The aim of the present study was to evaluate the clinicopathological, immunohistochemical, and molecular genetic features of gastrointestinal stromal tumors in Brazil and compare them with cases from other countries. Five hundred and thirteen cases were retrospectively analyzed. HE-stained sections and clinical information were reviewed and the immunohistochemical expression of CD117, CD34, smooth-muscle actin, S-100 protein, desmin, CD44v3 adhesion molecule, p53 protein, epidermal growth factor receptor, and Ki-67 antigen was studied using tissue microarrays. Mutation analysis of KIT and platelet-derived growth factor receptor-alpha genes was also performed. There was a slight female predominance (50.3%) and the median age at diagnosis was 59 years. The tumors were mainly located in the stomach (38.4%). Immunohistochemistry showed that CD117 was expressed in 95.7% of cases. Epidermal growth factor receptor expression was observed in 84.4% of tumors. p53 protein expression was found only in 2.6% of cases but all belonged to the high-risk group for aggressive behavior according to the National Institutes of Health consensus approach. No CD44v3 adhesion molecule expression was detected. KIT exon 11 mutations were the most frequent (62.2%). The present data confirm that gastrointestinal stromal tumors in Brazilian patients do not differ from tumors occurring in other countries.

Identificador

PATHOLOGY INTERNATIONAL, v.58, n.6, p.344-352, 2008

1320-5463

http://producao.usp.br/handle/BDPI/23526

10.1111/j.1440-1827.2008.02235.x

http://dx.doi.org/10.1111/j.1440-1827.2008.02235.x

Idioma(s)

eng

Publicador

WILEY-BLACKWELL

Relação

Pathology International

Direitos

restrictedAccess

Copyright WILEY-BLACKWELL

Palavras-Chave #Brazil #clinicopathological study #gastrointestinal stromal tumor #immunohistochemistry #mutation analysis #tissue microarray #CYCLE REGULATORY PROTEINS #GROWTH-FACTOR RECEPTOR #TERM-FOLLOW-UP #PROGNOSTIC-SIGNIFICANCE #INTRAMURAL LEIOMYOMAS #INTERSTITIAL-CELLS #P53 EXPRESSION #C-KIT #LEIOMYOSARCOMAS #MUTATIONS #Pathology
Tipo

article

original article

publishedVersion