Nonoperative Approaches to Rectal Cancer: A Critical Evaluation
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
19/10/2012
19/10/2012
2011
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Resumo |
A neoadjuvant multimodality approach with chemoradiation therapy (CRT) is the preferred treatment strategy for most distal rectal cancers. Significant downstaging and complete pathologic response may develop after this strategy, and there is still controversy regarding the management of these patients. In this setting, a nonoperative approach has been suggested in select patients with complete clinical response after thorough clinical, endoscopic, and radiologic assessment. However, the assessment of these patients is not straightforward and remains complex. Available data regarding this approach are limited to a single institution`s experience from retrospective analyses. Standardization of the assessment of tumor response and the development of radiological/molecular tools may clarify the role of no immediate surgery in patients with complete clinical response after neoadjuvant CRT. Advances in radiation and medical oncology could potentially lead to significant improvements in complete tumor regression rates, leading to an increase in importance of a minimally invasive approach in patients with rectal cancer. Semin Radiat Oncol 21:234-239 (C) 2011 Elsevier Inc. All rights reserved. |
Identificador |
SEMINARS IN RADIATION ONCOLOGY, v.21, n.3, p.234-239, 2011 1053-4296 http://producao.usp.br/handle/BDPI/23250 10.1016/j.semradonc.2011.02.010 |
Idioma(s) |
eng |
Publicador |
W B SAUNDERS CO-ELSEVIER INC |
Relação |
Seminars in Radiation Oncology |
Direitos |
closedAccess Copyright W B SAUNDERS CO-ELSEVIER INC |
Palavras-Chave | #NEOADJUVANT CHEMORADIATION THERAPY #PATHOLOGICAL COMPLETE RESPONSE #PREOPERATIVE RADIOTHERAPY #RANDOMIZED-TRIAL #POSTOPERATIVE CHEMORADIOTHERAPY #DELAYED SURGERY #LOCAL EXCISION #CHEMOTHERAPY #TUMOR #RADIATION #Oncology #Radiology, Nuclear Medicine & Medical Imaging |
Tipo |
article original article publishedVersion |