Individual vulnerability to escalated aggressive behavior by a low dose of alcohol: decreased serotonin receptor mRNA in the prefrontal cortex of male mice
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
19/10/2012
19/10/2012
2010
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Resumo |
Low to moderate doses of alcohol consumption induce heightened aggressive behavior in some, but not all individuals. Individual vulnerability for this nonadaptive behavior may be determined by an interaction of genetic and environmental factors with the sensitivity of alcohol`s effects on brain and behavior. We used a previously established protocol for alcohol oral self-administration and characterized alcohol-heightened aggressive (AHA) mice as compared with alcohol non-heightened (ANA) counterparts. A week later, we quantified mRNA steady state levels of several candidate genes in the serotonin [5-hydroxytryptamine (5-HT)] system in different brain areas. We report a regionally selective and significant reduction of all 5-HT receptor subtype transcripts, except for 5-HT(3), in the prefrontal cortex of AHA mice. Comparable gene expression profile was previously observed in aggressive mice induced by social isolation or by an anabolic androgenic steroid. Additional change in the 5-HT(1B) receptor transcripts was seen in the amygdala and hypothalamus of AHA mice. In both these areas, 5-HT(1B) mRNA was elevated when compared with ANA mice. In the hypothalamus, AHA mice also showed increased transcripts for 5-HT(2A) receptor. In the midbrain, 5-HT synthetic enzyme, 5-HT transporter and 5-HT receptors mRNA levels were similar between groups. Our results emphasize a role for postsynaptic over presynaptic 5-HT receptors in mice which showed escalated aggression after the consumption of a moderate dose of alcohol. This gene expression profile of 5-HT neurotransmission components in the brain of mice may suggest a vulnerability trait for alcohol-heightened aggression. National Institute of Health (NIH)[AA013983] Sao Paulo State Foundation for Research Support (FAPESP)[06/06904-5] National Institute of Science and Technology (INCT-CNPq, Brazil) CAPES (Brazil) |
Identificador |
GENES BRAIN AND BEHAVIOR, v.9, n.1, p.110-119, 2010 1601-1848 http://producao.usp.br/handle/BDPI/23126 10.1111/j.1601-183X.2009.00544.x |
Idioma(s) |
eng |
Publicador |
WILEY-BLACKWELL |
Relação |
Genes Brain and Behavior |
Direitos |
restrictedAccess Copyright WILEY-BLACKWELL |
Palavras-Chave | #5-HT(1B) receptor #aggression #amygdala #gene expression #hypothalamus #midbrain #real-time PCR #serotonin #transcription #violence #BASOLATERAL NUCLEAR GROUP #5-HT1B RECEPTORS #HEIGHTENED AGGRESSION #IMPULSIVE AGGRESSION #SOCIAL INSTIGATION #DOWN-REGULATION #DORSAL RAPHE #AGONISTS #AMYGDALA #NEURONS #Behavioral Sciences #Neurosciences |
Tipo |
article original article publishedVersion |