Obstructive Sleep Apnea, Masked Hypertension, and Arterial Stiffness in Men


Autoria(s): DRAGER, Luciano F.; DIEGUES-SILVA, Luzia; DINIZ, Patricia M.; BORTOLOTTO, Lutz A.; PEDROSA, Rodrigo P.; COUTO, Roberta B.; MARCONDES, Bianca; GIORGI, Dante M. A.; LORENZI-FILHO, Geraldo; KRIEGER, Eduardo M.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2010

Resumo

BACKGROUND Obstructive sleep apnea (OSA) is an established cause of hypertension However, it is not clear whether the frequency of masked hypertension in patients with OSA and whether OSA have an independent role on arterial stiffness taking into account ambulatory blood pressure (BP) monitoring (ABPM) METHODS We evaluated 61 male normotensive participants as determined by casual clinic BP level <140/90 mm Hg without clinical evidence of cardiovascular disease and on no medications (43 patients with moderate-to-severe OSA (apnea-hypopnea index (AHI) >= 15 events/hour by polysomnography) and 18 age- and body mass index-matched controls without OSA (AHl <5 events/hour)) Pulse wave velocity (PWV), an index of arterial stiffness, and 24-h ABPM were performed in a blinded fashion Masked hypertension was defined when abnormal daytime ABPM was >= 135 or >= 85 mm Hg RESULTS The AHI and lowest oxygen saturation were 26 +/- 16 and 90 +/- 2 vs 528 +/- 210 events/hour and 75 +/- 10% for controls and OSA patients, respectively, P < 0 001. Compared with controls, patients with OSA had higher office systolic BP (113 +/- 9 vs 118 +/- 10 mm Hg, P=0 05) and a higher unadjusted proportion of masked hypertension (2 controls (11.1%)vs 13 patients (30 2%), P < 005) PWV was 87 +/- 0.7, 9.4 +/- 1.0, and 10.6 +/- 1.1 m/s in the control, OSA without and with masked hypertension groups, respectively (P < 0 01 for each comparison) Multiple regression showed that systolic daytime ABPM and the lowest oxygen saturation were independently related to PWV (adjusted R(2) = 0 34, P < 0 01) CONCLUSIONS Patients with OSA presented a higher unadjusted rate of masked hypertension than matched controls. Lowest oxygen saturation has an independent association with arterial stiffness

FAPESP

CNPq

Fundacao Zerbini

Identificador

AMERICAN JOURNAL OF HYPERTENSION, v.23, n.3, p.249-254, 2010

0895-7061

http://producao.usp.br/handle/BDPI/23119

10.1038/ajh.2009.246

http://dx.doi.org/10.1038/ajh.2009.246

Idioma(s)

eng

Publicador

NATURE PUBLISHING GROUP

Relação

American Journal of Hypertension

Direitos

closedAccess

Copyright NATURE PUBLISHING GROUP

Palavras-Chave #arterial stiffness, blood pressure, cardiovascular disease, hypertension #masked hypertension #sleep apnea #24-HOUR BLOOD-PRESSURE #EARLY SIGNS #ATHEROSCLEROSIS #RISK #ROTTERDAM #DAMAGE #HOME #Peripheral Vascular Disease
Tipo

article

original article

publishedVersion