Cytokine Profile in Pleural Fluid and Serum After Lung Transplantation


Autoria(s): TEIXEIRA, R. H. O. B.; ANTONANGELO, L.; VARGAS, F. S.; CARAMORI, M. L.; AFONSO JR., J. E.; ACENCIO, M. M. P.; PEGO-FERNANDES, P. M.; JATENE, F. B.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2010

Resumo

Background. Lung transplantation is the procedure of choice in several end-stage lung diseases. Despite improvements in surgical techniques and immunosuppression, early postoperative complications occur frequently. Objective. To evaluate the pleural inflammatory response after surgery. Patients and Methods. Twenty patients aged 18 to 63 years underwent unilateral or bilateral lung transplantation between August 2006 and March 2008. Proinflammatory cytokines interleukin (IL)-1 beta, IL-6, and IL-8 and vascular endothelial growth factor in pleural fluid and serum were analyzed. For cytokine evaluation, 20-mL samples of pleural fluid and blood (right, left, or both chest cavities) were obtained at 6 hours after surgery and daily until removal of the chest tube or for a maximum of 10 days. Data were analyzed using analysis of variance followed by the Holm-Sidak test. Results. All effusions were exudates according to Light`s criteria. Pleural fluid cytokine concentrations were highest at 6 hours after surgery. Serum concentrations were lower than those in pleural fluid, and IL-1 beta, IL-6, and IL-8 were undetectable at all time points. Conclusions. There is a peak concentration of inflammatory cytokines in the first 6 hours after transplantation, probably reflecting the effects of surgical manipulation. The decrease observed from postoperative day 1 and thereafter suggests the action of the immunosuppression agents and a temporal reduction in pleural inflammation.

Identificador

TRANSPLANTATION PROCEEDINGS, v.42, n.2, p.531-534, 2010

0041-1345

http://producao.usp.br/handle/BDPI/23110

10.1016/j.transproceed.2010.01.033

http://dx.doi.org/10.1016/j.transproceed.2010.01.033

Idioma(s)

eng

Publicador

ELSEVIER SCIENCE INC

Relação

Transplantation Proceedings

Direitos

restrictedAccess

Copyright ELSEVIER SCIENCE INC

Palavras-Chave #Immunology #Surgery #Transplantation
Tipo

article

original article

publishedVersion