Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
19/10/2012
19/10/2012
2010
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Resumo |
Dendritic cells (DCs)-based vaccine was demonstrated to increase HIV specific cellular immune response; however, in some HIV-infected patients, the response to the vaccine resulted to be not effective. In order to understand if the outcome of the vaccination may be influenced by the host`s genome and natural immunity, we studied the innate immune genome of HIV-infected patients previously vaccinated with DCs. We identified 15 SNPs potentially associated with the response to the immuno-treatment and two SNPs significantly associated with the modulation of the response to the DC vaccine: MBL2 rs10824792 and NOS1 rs693534. These two SNPs were also studied in different ethnic groups (Brazilians, African and Caucasian) of HIV-infected, exposed uninfected and unexposed uninfected subjects. The HIV positive Caucasian patients were also characterized by different disease progressions. Our findings suggest that, independently and/or in addition to other variables. the host`s genome could significantly contribute to the modulation of the response to the DC vaccine. (C) 2009 Elsevier Ltd. All rights reserved. IRCCS Burlo Garofolo[RC03/04] IRCCS Burlo Garofolo[RC07/08] FACEPE[APQ-1130-2.02/08] FACEPE[APQ-0020-4.01/08] CNPq[474566/2008-0] |
Identificador |
VACCINE, v.28, n.10, p.2201-2206, 2010 0264-410X http://producao.usp.br/handle/BDPI/23099 10.1016/j.vaccine.2009.12.056 |
Idioma(s) |
eng |
Publicador |
ELSEVIER SCI LTD |
Relação |
Vaccine |
Direitos |
restrictedAccess Copyright ELSEVIER SCI LTD |
Palavras-Chave | #Dendritic cell immunotherapy #Innate immunity #HIV infection #MANNOSE-BINDING LECTIN #NITRIC-OXIDE #INFECTION #DISEASE #MONOCYTES #VACCINE #LOCUS #MBL #Immunology #Medicine, Research & Experimental |
Tipo |
article original article publishedVersion |