Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment


Autoria(s): SEGAT, Ludovica; BRANDAO, Lucas A. C.; GUIMARES, Rafael L.; PONTILLO, Alessandra; ATHANASAKIS, Emmanouil; OLIVEIRA, Rafael Martins de; ARRAES, Luiz C.; LIMA FILHO, Jose Luiz de; CROVELLA, Sergio
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2010

Resumo

Dendritic cells (DCs)-based vaccine was demonstrated to increase HIV specific cellular immune response; however, in some HIV-infected patients, the response to the vaccine resulted to be not effective. In order to understand if the outcome of the vaccination may be influenced by the host`s genome and natural immunity, we studied the innate immune genome of HIV-infected patients previously vaccinated with DCs. We identified 15 SNPs potentially associated with the response to the immuno-treatment and two SNPs significantly associated with the modulation of the response to the DC vaccine: MBL2 rs10824792 and NOS1 rs693534. These two SNPs were also studied in different ethnic groups (Brazilians, African and Caucasian) of HIV-infected, exposed uninfected and unexposed uninfected subjects. The HIV positive Caucasian patients were also characterized by different disease progressions. Our findings suggest that, independently and/or in addition to other variables. the host`s genome could significantly contribute to the modulation of the response to the DC vaccine. (C) 2009 Elsevier Ltd. All rights reserved.

IRCCS Burlo Garofolo[RC03/04]

IRCCS Burlo Garofolo[RC07/08]

FACEPE[APQ-1130-2.02/08]

FACEPE[APQ-0020-4.01/08]

CNPq[474566/2008-0]

Identificador

VACCINE, v.28, n.10, p.2201-2206, 2010

0264-410X

http://producao.usp.br/handle/BDPI/23099

10.1016/j.vaccine.2009.12.056

http://dx.doi.org/10.1016/j.vaccine.2009.12.056

Idioma(s)

eng

Publicador

ELSEVIER SCI LTD

Relação

Vaccine

Direitos

restrictedAccess

Copyright ELSEVIER SCI LTD

Palavras-Chave #Dendritic cell immunotherapy #Innate immunity #HIV infection #MANNOSE-BINDING LECTIN #NITRIC-OXIDE #INFECTION #DISEASE #MONOCYTES #VACCINE #LOCUS #MBL #Immunology #Medicine, Research & Experimental
Tipo

article

original article

publishedVersion