A cross-sectional study on the clinical and immunological spectrum of human Leishmania (L.) infantum chagasi infection in the Brazilian Amazon region
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
19/10/2012
19/10/2012
2009
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Resumo |
The objectives of this study were to identify individuals with symptomatic and/or asymptomatic infection due to Leishmania (L.) infantum chagasi; to study the two types of infection, both clinically and immunologically, and to determine the prevalence rate of infection at the beginning of the study. This was a cross-sectional study with a cohort of 946 individuals, of both genders, from the age of 1 year, living in the municipality of Barcarena, PA, Brazil, an area endemic for American visceral leishmaniasis (AVL). The leishmanin skin test (LST) and the indirect fluorescent test (IFAT), were used for the diagnosis of infection. One hundred and twenty cases of infection were diagnosed, with a prevalence rate of 12.6%; eight cases showed high seroreactivity (1280-10240, IgG) in IFAT and no LST reaction; four of these cases were typical AVL and four had subclinical oligosymptomatic infection. Using two immunological methods with a clinical examination of the infected individuals enabled the identification of five clinical-immunological profiles which may promote a better understanding of the interaction between L. (L.) i. chagasi and the human immune response: asymptomatic infection (AI) 73.4%; subclinical resistant infection (SRI) 15%; subclinicat oligosymptomatic infection (SOI) 3%; symptomatic infection (AVL) 3% and indeterminate initial infection (III) 5%. (C) 2009 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved. Instituto Evandro Chagas (Secretaria de Vigilancia em Saude, Ministerio da Saude, Brazil) Instituto de Medicina Tropical (Universidade Federal do Para, Brazil) Wellcome Trust (London) Universidade de São Paulo - Laboratorio de Investigacao Medica[(LIM)-50] - FM-USP Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Brazil[06/56319-1] |
Identificador |
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, v.103, n.12, p.1250-1256, 2009 0035-9203 http://producao.usp.br/handle/BDPI/22799 10.1016/j.trstmh.2009.06.010 |
Idioma(s) |
eng |
Publicador |
ELSEVIER SCIENCE INC |
Relação |
Transactions of the Royal Society of Tropical Medicine and Hygiene |
Direitos |
restrictedAccess Copyright ELSEVIER SCIENCE INC |
Palavras-Chave | #Leishmania infantum chagasi #Infection #Clinical examination #Immunologic tests #Cross-sectional study #Brazil #AMERICAN VISCERAL LEISHMANIASIS #ENDEMIC AREA #SKIN-TEST #NORTHEASTERN BRAZIL #DONOVANI INFECTION #SUBCLINICAL FORM #EASTERN SUDAN #RISK-FACTORS #KALA-AZAR #ETHIOPIA #Public, Environmental & Occupational Health #Tropical Medicine |
Tipo |
article original article publishedVersion |