The frontal assessment battery (FAB) reveals neurocognitive dysfunction in substance-dependent individuals in distinct executive domains: Abstract reasoning, motor programming, and cognitive flexibility


Autoria(s): CUNHA, Paulo Jannuzzi; NICASTRI, Sergio; ANDRADE, Arthur Guerra de; BOLLA, Karen I.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2010

Resumo

Substance-dependence is highly associated with executive cognitive function (ECF) impairments. However. considering that it is difficult to assess ECF clinically, the aim of the present study was to examine the feasibility of a brief neuropsychological tool (the Frontal Assessment Battery FAB) to detect specific ECF impairments in a sample of substance-dependent individuals (SDI). Sixty-two subjects participated in this study. Thirty DSM-IV-diagnosed SDI, after 2 weeks of abstinence, and 32 healthy individuals (control group) were evaluated with FAD and other ECF-related tasks: digits forward (DF), digits backward (DB), Stroop Color Word Test (SCWT), and Wisconsin Card Sorting Test (WCST). SDI did not differ from the control group on sociodemographic variables or IQ. However, SDI performed below the controls in OF, DB, and FAB. The SDI were cognitively impaired in 3 of the 6 cognitive domains assessed by the FAB: abstract reasoning, motor programming, and cognitive flexibility. The FAB correlated with DF, SCWT, and WCST. In addition, some neuropsychological measures were correlated with the amount of alcohol, cannabis, and cocaine use. In conclusion, SDI performed more poorly than the comparison group on the FAB and the FAB`s results were associated with other ECF-related tasks. The results suggested a negative impact of alcohol, cannabis, and cocaine use on the ECF. The FAB may be useful in assisting professionals as an instrument to screen for ECF-related deficits in SDI. (C) 2010 Elsevier Ltd. All rights reserved.

Identificador

ADDICTIVE BEHAVIORS, v.35, n.10, p.875-881, 2010

0306-4603

http://producao.usp.br/handle/BDPI/22513

10.1016/j.addbeh.2010.05.005

http://dx.doi.org/10.1016/j.addbeh.2010.05.005

Idioma(s)

eng

Publicador

PERGAMON-ELSEVIER SCIENCE LTD

Relação

Addictive Behaviors

Direitos

restrictedAccess

Copyright PERGAMON-ELSEVIER SCIENCE LTD

Palavras-Chave #Neuropsychology #Prefrontal cortex #Substance use #Alcohol #Cannabis #Cocaine #ABSTINENT COCAINE ABUSERS #PREFRONTAL CORTEX #FRONTOTEMPORAL DEMENTIA #ORBITOFRONTAL CORTEX #DECISION-MAKING #POLYSUBSTANCE ABUSERS #ANTERIOR CINGULATE #TEST-PERFORMANCE #DRUG-ABUSERS #ADDICTION #Psychology, Clinical #Substance Abuse
Tipo

article

original article

publishedVersion