CHRONIC ACTIVE EPSTEIN-BARR VIRUS INFECTION MIMICKING HENOCH-SCHONLEIN PURPURA


Autoria(s): GUISSA, Vanessa R.; ARAGAO, Paula A. de; MARQUES, Heloisa H. S.; JACOB, Cristina M. A.; SILVA, Clovis A.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2010

Resumo

Introduction: Chronic active Epstein-Barr virus (CAEBV) infection is characterized by chronic or recurrent symptoms for at least 3 months, such as fever, hepatosplenomegaly and lymphadenopathy. The diagnosis is established due to the presence of anti-EBV antibodies or isolation of this infectious agent in affected tissues. Three cases of CAEBV infection mimicking Henoch-Schonlein purpura (HSP) were described. Case 1: Female 3-year old patient with cervical adenomegaly, anemia and fever developed palpable purpura, haematuria and arthritis. CAEBV infection was established by serology test. She received methylprednisolone and acyclovir. She had generalized lymphadenopathy, hepatomegaly, splenomegaly, disseminated intravascular coagulation and deceased. Case 2: Male 12-year old patient with persistent anemia, lymphadenopathy, hepatomegaly and splenomegaly had CAEBV infection diagnosis by serology test. He developed purpura and arthritis and received methylprednisolone. Case 3: Male 13-year old patient had purpura, abdominal pain, haematuria, hepatomegaly, splenomegaly, lymphadenopathy, anemia and elevated liver enzymes. The cervical lymph node biopsy was positive to EBV infection. He received methylprednisolone and acyclovir, developing acute fulminant hepatitis and death. Discussion: CAEBV infection mimicking HSP was rarely observed in our population

Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPQ[300248/2008-3]

Federico Foundation

Identificador

ACTA REUMATOLOGICA PORTUGUESA, v.35, n.4, p.513-517, 2010

0303-464X

http://producao.usp.br/handle/BDPI/22454

http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000286158600013&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord

Idioma(s)

eng

Publicador

MEDFARMA-EDICOES MEDICAS, LDA

Relação

Acta Reumatologica Portuguesa

Direitos

restrictedAccess

Copyright MEDFARMA-EDICOES MEDICAS, LDA

Palavras-Chave #Henoch-Schoenlein Purpura #Chronic Active Epstein-Barr Virus Infection #Children #LYMPHOPROLIFERATIVE-DISORDER #MONONUCLEOSIS #NEPHRITIS #DISEASE #Rheumatology
Tipo

article

original article

publishedVersion