Evaluation of melatonin on the precocious puberty: a pilot study


Autoria(s): HOLANDA, Felisbela Soares de; TUFIK, Sergio; BIGNOTTO, Magda; MAGANHIN, Carla G.; VIEIRA, Lucia Helena Laprano; BARACAT, Edmund C.; SOARES JR., Jose Maria
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2011

Resumo

Objective. To evaluate the effect of 6-sulphatoxymelatonin on the sleep quality of girls with precocious puberty. Study design. Ninety-nine girls were divided into three groups: GI, precocious puberty; GII, normal prepubescent; GIII, normal puberty. Questionnaires containing demographic and clinical data were applied. Blood was collected for hormonal evaluation for 6-sulphatoxymelatonin. The modified Rush Sleep Diary was used. Results. The levels of 6-sulphatoxymelatonin were highest in the group without pubertal development (75.23 +/- 10.84 ng/ml), second highest in the group with normal puberty (45.66 +/- 3.87 ng/ml, p < 0.001) and lowest in the group with true precocious puberty (37.04 +/- 5.47 ng/ml). The amount of day sleep was greater in the group without pubertal development compared to other groups. Conclusion. Despite the sleep data, melatonin may be involved in the precocious puberty process.

Capes, Brasilia-Br

Identificador

GYNECOLOGICAL ENDOCRINOLOGY, v.27, n.8, p.519-523, 2011

0951-3590

http://producao.usp.br/handle/BDPI/22372

10.3109/09513590.2010.501888

http://dx.doi.org/10.3109/09513590.2010.501888

Idioma(s)

eng

Publicador

INFORMA HEALTHCARE

Relação

Gynecological Endocrinology

Direitos

closedAccess

Copyright INFORMA HEALTHCARE

Palavras-Chave #Girls #melatonin #precocious puberty #sleep #PROGESTERONE-RECEPTOR #CIRCADIAN-RHYTHMS #SECRETION #SLEEP #WOMEN #GIRLS #AGE #ADOLESCENCE #ESTROGEN #HUMANS #Endocrinology & Metabolism #Obstetrics & Gynecology
Tipo

article

original article

publishedVersion