Endometrial leukemia inhibitory factor as a predictor of pregnancy after in vitro fertilization
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
19/10/2012
19/10/2012
2008
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Resumo |
Objective: To determine whether there is an association between endometrial expression of leukemia inhibitory factor (LIF) in the luteal phase of the menstrual cycle preceding in vitro fertilization (IVF) and treatment outcome. Methods: Biopsy specimens from the endometria of 52 women in the luteal. phase were immunostained against LIF Embryo culture and transfer were done according to standard procedures. Results: Clinical pregnancy occurred in 39% of the women following IVF, and strong endometrial immunohistochemical staining for LIF was associated with pregnancy (P=0.01). The women with a strong LIF expression had a 6.4-fold higher chance of becoming pregnant than those with weaker intensities (P=0.005). Conclusion: Endometrial expression of LIF during the luteal phase can be used as a predictor of IVF success. (C) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved. |
Identificador |
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, v.102, n.1, p.23-27, 2008 0020-7292 http://producao.usp.br/handle/BDPI/22359 10.1016/j.ijgo.2007.12.005 |
Idioma(s) |
eng |
Publicador |
ELSEVIER IRELAND LTD |
Relação |
International Journal of Gynecology & Obstetrics |
Direitos |
restrictedAccess Copyright ELSEVIER IRELAND LTD |
Palavras-Chave | #endometrial biopsy #endometrial receptivity #in vitro fertilization #leukemia inhibitory factor #luteal phase #tissue microarray #EMBRYO IMPLANTATION #INFERTILE WOMEN #FACTOR LIF #EXPRESSION #CYCLES #PINOPODES #FERTILE #WINDOW #Obstetrics & Gynecology |
Tipo |
article original article publishedVersion |