Endometrial leukemia inhibitory factor as a predictor of pregnancy after in vitro fertilization


Autoria(s): SERAFINI, Paulo; ROCHA, Andre M.; OSORIO, Cyntia T.; SILVA, Ismael da; MOTTA, Eduardo L.; BARACAT, Edmund C.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2008

Resumo

Objective: To determine whether there is an association between endometrial expression of leukemia inhibitory factor (LIF) in the luteal phase of the menstrual cycle preceding in vitro fertilization (IVF) and treatment outcome. Methods: Biopsy specimens from the endometria of 52 women in the luteal. phase were immunostained against LIF Embryo culture and transfer were done according to standard procedures. Results: Clinical pregnancy occurred in 39% of the women following IVF, and strong endometrial immunohistochemical staining for LIF was associated with pregnancy (P=0.01). The women with a strong LIF expression had a 6.4-fold higher chance of becoming pregnant than those with weaker intensities (P=0.005). Conclusion: Endometrial expression of LIF during the luteal phase can be used as a predictor of IVF success. (C) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

Identificador

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, v.102, n.1, p.23-27, 2008

0020-7292

http://producao.usp.br/handle/BDPI/22359

10.1016/j.ijgo.2007.12.005

http://dx.doi.org/10.1016/j.ijgo.2007.12.005

Idioma(s)

eng

Publicador

ELSEVIER IRELAND LTD

Relação

International Journal of Gynecology & Obstetrics

Direitos

restrictedAccess

Copyright ELSEVIER IRELAND LTD

Palavras-Chave #endometrial biopsy #endometrial receptivity #in vitro fertilization #leukemia inhibitory factor #luteal phase #tissue microarray #EMBRYO IMPLANTATION #INFERTILE WOMEN #FACTOR LIF #EXPRESSION #CYCLES #PINOPODES #FERTILE #WINDOW #Obstetrics & Gynecology
Tipo

article

original article

publishedVersion