Characterization of Leishmania (Leishmania) amazonensis promastigotes resistant to pentamidine
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
19/10/2012
19/10/2012
2008
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| Resumo |
Pentamidine is a second-line agent used in the treatment of leishmaniasis and its mode of action and mechanism of resistance is not well understood. It was previously demonstrated that transfection of promastigotes and amastigotes with the ABC transporter PRP1 gene confers resistance to pentamidine. To further clarify this point, we generated Leishmania amazonensis mutants resistant to pentamidine. Our results indicated that this ABC transporter is not associated with pentamidine resistance in lines generated by drug pressure through amplification or overexpression mechanisms of PRP1 gene. (C) 2008 Elsevier Inc. All rights reserved. CNPq[473121-2] FAPESP[06/04656-4] Universidade de São Paulo - LIM-48-FM-USP CAPES |
| Identificador |
EXPERIMENTAL PARASITOLOGY, v.120, n.1, p.98-102, 2008 0014-4894 http://producao.usp.br/handle/BDPI/22172 10.1016/j.exppara.2008.03.018 |
| Idioma(s) |
eng |
| Publicador |
ACADEMIC PRESS INC ELSEVIER SCIENCE |
| Relação |
Experimental Parasitology |
| Direitos |
restrictedAccess Copyright ACADEMIC PRESS INC ELSEVIER SCIENCE |
| Palavras-Chave | #Leishmania #pentamidine #drug resistance #ABC transporter #MULTIDRUG-RESISTANCE #DRUG-RESISTANCE #GENE-EXPRESSION #P-GLYCOPROTEIN #AMPLIFICATION #DONOVANI #DNA #TRANSPORTER #MODULATION #PARASITE #Parasitology |
| Tipo |
article original article publishedVersion |
