Pathogenesis of Endemic Pemphigus Foliaceus
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
19/10/2012
19/10/2012
2011
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| Resumo |
Pemphigus refers to a group of human autoimmune blistering diseases involving skin and/or mucous membranes. Endemic pemphigus foliaceus (EPF), or fogo selvagem is an organ-specific autoimmune blistering disease, first reported in the beginning of the 20th century in rural areas of Brazil. The disease follows the course of streams and creeks, and vanishes after urbanization of the endemic areas. The auto-antigen related to EPF is desmoglein 1, a 160 kDa glycoprotein of the desmossomal core, targeted by in situ and circulating IgG autoantibodies, mainly of the IgG4 subclass. Conselho Nacional de Pesquisa-CNPq[471] Conselho Nacional de Pesquisa-CNPq[257/2008-7] NIH[R01-AR30281] NIH[RO1-AR32599] NIH[T32 AR07369] |
| Identificador |
DERMATOLOGIC CLINICS, v.29, n.3, p.413-+, 2011 0733-8635 http://producao.usp.br/handle/BDPI/22003 10.1016/j.det.2011.03.014 |
| Idioma(s) |
eng |
| Publicador |
W B SAUNDERS CO-ELSEVIER INC |
| Relação |
Dermatologic Clinics |
| Direitos |
restrictedAccess Copyright W B SAUNDERS CO-ELSEVIER INC |
| Palavras-Chave | #Autoimmunity #Pemphigus #Desmoglein #FOGO-SELVAGEM #BRAZILIAN PEMPHIGUS #AMERINDIAN RESERVATION #HIGH PREVALENCE #ANTIBODIES #PHENOTYPE #VULGARIS #EPITOPE #FOCUS #Dermatology |
| Tipo |
article original article publishedVersion |
