Neutrophils recruitment during sepsis: Critical points and crossroads
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
19/10/2012
19/10/2012
2009
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Resumo |
The mechanisms that initiate an inflammatory systemic response to a bacterial infection lead to a high mortality and constitute the first cause of death in Critical Care Units (ICU`s). Sepsis is a poorly understood disease and despite life support techniques and the administration of antibiotics, not much more can be done to improve its diagnosis and treatment. The present article has as main objective to discuss the role of neutrophils recruitment in sepsis, dissecting the molecular mechanisms implicated in this complex process and its importance to the pathogenesis of this outstanding cause of death. |
Identificador |
FRONTIERS IN BIOSCIENCE, v.14, p.4464-4476, 2009 1093-9946 http://producao.usp.br/handle/BDPI/21621 10.2741/3542 |
Idioma(s) |
eng |
Publicador |
FRONTIERS IN BIOSCIENCE INC |
Relação |
Frontiers in Bioscience |
Direitos |
restrictedAccess Copyright FRONTIERS IN BIOSCIENCE INC |
Palavras-Chave | #Neutrophil #Sepsis #Adhesion #PARP #nitric oxide #Fc receptors #ICAM #VCAM #Review #INTERCELLULAR-ADHESION MOLECULE-1 #DIABETIC ENDOTHELIAL DYSFUNCTION #MULTICENTER CLINICAL-TRIAL #PLACEBO-CONTROLLED TRIAL #TOLL-LIKE RECEPTORS #POLY(ADP-RIBOSE) POLYMERASE #DEFICIENT MICE #DOUBLE-BLIND #P-SELECTIN #MONOCLONAL-ANTIBODY #Biochemistry & Molecular Biology #Cell Biology |
Tipo |
article original article publishedVersion |