Neutrophils recruitment during sepsis: Critical points and crossroads


Autoria(s): SILVA, Fabiano Pinheiro da; SORIANO, Francisco Garcia
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2009

Resumo

The mechanisms that initiate an inflammatory systemic response to a bacterial infection lead to a high mortality and constitute the first cause of death in Critical Care Units (ICU`s). Sepsis is a poorly understood disease and despite life support techniques and the administration of antibiotics, not much more can be done to improve its diagnosis and treatment. The present article has as main objective to discuss the role of neutrophils recruitment in sepsis, dissecting the molecular mechanisms implicated in this complex process and its importance to the pathogenesis of this outstanding cause of death.

Identificador

FRONTIERS IN BIOSCIENCE, v.14, p.4464-4476, 2009

1093-9946

http://producao.usp.br/handle/BDPI/21621

10.2741/3542

http://dx.doi.org/10.2741/3542

Idioma(s)

eng

Publicador

FRONTIERS IN BIOSCIENCE INC

Relação

Frontiers in Bioscience

Direitos

restrictedAccess

Copyright FRONTIERS IN BIOSCIENCE INC

Palavras-Chave #Neutrophil #Sepsis #Adhesion #PARP #nitric oxide #Fc receptors #ICAM #VCAM #Review #INTERCELLULAR-ADHESION MOLECULE-1 #DIABETIC ENDOTHELIAL DYSFUNCTION #MULTICENTER CLINICAL-TRIAL #PLACEBO-CONTROLLED TRIAL #TOLL-LIKE RECEPTORS #POLY(ADP-RIBOSE) POLYMERASE #DEFICIENT MICE #DOUBLE-BLIND #P-SELECTIN #MONOCLONAL-ANTIBODY #Biochemistry & Molecular Biology #Cell Biology
Tipo

article

original article

publishedVersion