Menstrual and hormonal alterations in juvenile systemic lupus erythematosus


Autoria(s): MEDEIROS, P. B.; FEBRONIO, M. V.; BONFA, E.; BORBA, E. F.; TAKIUTI, A. D.; SILVA, C. A. A.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2009

Resumo

Menstrual cycles of 30 patients with juvenile systemic lupus erythematosus (JSLE) were compared with 30 age-matched controls. The mean age of patients with JSLE and controls was similar (17.4 +/- 3.2 vs 17.06 +/- 2.08 years, P = 0.66). The mean menarche age was higher in JSLE than controls (13.13 +/- 1.4 vs 11.56 +/- 1.5 years, P = 0.0008). On the contrary, the mean maternal menarche age was similar in both groups (P = 0.62). Menstrual abnormalities and longer length cycles were more frequently observed in JSLE than controls (63% vs 10%, P = 0.0001; 23% vs 0%, P = 0.0105, respectively). The median of follicle stimulating hormone was significantly higher in patients with JSLE compared with controls (4.6 vs 3.4 IU/L, P = 0.0207), and the median of progesterone was lower (32.5 vs 70 ng/mL, P = 0.0033). The median Of luteinizing hormone was lower in patients with JSLE with menstrual abnormalities versus normal cycles (2.9 vs 5.5 IU/L, P = 0.019) and both had a high percentage of decreased progesterone levels (63% vs 73%, P = 0.70). Our findings support the notion that menstrual disturbances are frequent and may be associated with pituitary dysfunction leading to a decreased progesterone production. We also reported that in spite of premature ovarian failure being a rare event in JSLE the follicular reserve seems to be low regardless of intravenous cyclophosphamide treatment. Lupus (2009) 18, 38-43.

Conselho Nacional de Desenvolvimento Clentifico e Tecnologico - CNPQ[305468/2006-5]

Conselho Nacional de Desenvolvimento Clentifico e Tecnologico - CNPQ[302469/2005-2]

Federico Foundation

Identificador

LUPUS, v.18, n.1, p.38-43, 2009

0961-2033

http://producao.usp.br/handle/BDPI/21620

10.1177/0961203308094652

http://dx.doi.org/10.1177/0961203308094652

Idioma(s)

eng

Publicador

SAGE PUBLICATIONS LTD

Relação

Lupus

Direitos

restrictedAccess

Copyright SAGE PUBLICATIONS LTD

Palavras-Chave #adolescent #hormone #juvenile systemic lupus erythematosus #menarche #menstrual abnormalities #OVARIAN FAILURE #RISK-FACTORS #DISEASE-ACTIVITY #CYCLOPHOSPHAMIDE THERAPY #PULSE CYCLOPHOSPHAMIDE #CHILDHOOD #WOMEN #AMENORRHEA #Rheumatology
Tipo

article

original article

publishedVersion