Menstrual and hormonal alterations in juvenile systemic lupus erythematosus
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
19/10/2012
19/10/2012
2009
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Resumo |
Menstrual cycles of 30 patients with juvenile systemic lupus erythematosus (JSLE) were compared with 30 age-matched controls. The mean age of patients with JSLE and controls was similar (17.4 +/- 3.2 vs 17.06 +/- 2.08 years, P = 0.66). The mean menarche age was higher in JSLE than controls (13.13 +/- 1.4 vs 11.56 +/- 1.5 years, P = 0.0008). On the contrary, the mean maternal menarche age was similar in both groups (P = 0.62). Menstrual abnormalities and longer length cycles were more frequently observed in JSLE than controls (63% vs 10%, P = 0.0001; 23% vs 0%, P = 0.0105, respectively). The median of follicle stimulating hormone was significantly higher in patients with JSLE compared with controls (4.6 vs 3.4 IU/L, P = 0.0207), and the median of progesterone was lower (32.5 vs 70 ng/mL, P = 0.0033). The median Of luteinizing hormone was lower in patients with JSLE with menstrual abnormalities versus normal cycles (2.9 vs 5.5 IU/L, P = 0.019) and both had a high percentage of decreased progesterone levels (63% vs 73%, P = 0.70). Our findings support the notion that menstrual disturbances are frequent and may be associated with pituitary dysfunction leading to a decreased progesterone production. We also reported that in spite of premature ovarian failure being a rare event in JSLE the follicular reserve seems to be low regardless of intravenous cyclophosphamide treatment. Lupus (2009) 18, 38-43. Conselho Nacional de Desenvolvimento Clentifico e Tecnologico - CNPQ[305468/2006-5] Conselho Nacional de Desenvolvimento Clentifico e Tecnologico - CNPQ[302469/2005-2] Federico Foundation |
Identificador |
LUPUS, v.18, n.1, p.38-43, 2009 0961-2033 http://producao.usp.br/handle/BDPI/21620 10.1177/0961203308094652 |
Idioma(s) |
eng |
Publicador |
SAGE PUBLICATIONS LTD |
Relação |
Lupus |
Direitos |
restrictedAccess Copyright SAGE PUBLICATIONS LTD |
Palavras-Chave | #adolescent #hormone #juvenile systemic lupus erythematosus #menarche #menstrual abnormalities #OVARIAN FAILURE #RISK-FACTORS #DISEASE-ACTIVITY #CYCLOPHOSPHAMIDE THERAPY #PULSE CYCLOPHOSPHAMIDE #CHILDHOOD #WOMEN #AMENORRHEA #Rheumatology |
Tipo |
article original article publishedVersion |