Changes in purines concentration in the cerebrospinal fluid of patients experiencing pain: A case-control study
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
19/10/2012
19/10/2012
2010
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| Resumo |
This study analyzes the relationship between extracellular purines and pain perception in humans. Cerebrospinal fluid (CSF) levels of purines and their metabolites were compared between patients displaying acute and/or chronic pain syndromes and control subjects. The CSF levels of IMP, inosine, guanosine and uric acid were significantly increased in the chronic pain group and correlated with pain severity (P<0.05). Patients displaying both chronic and acute pain presented similar changes in the CSF purines concentration (P<0.05). However, in the acute pain group, only CSF inosine and uric acid levels were significantly increased (P<0.05). These findings suggest that purines, in special inosine, guanosine and uric acid, are associated with the spinal mechanisms underlying nociception. (C) 2010 Elsevier Ireland Ltd. All rights reserved. FINEP[01.06.0842-00] CNPq CAPES FAPERGS UFRGS INCT for Excitotoxicity and neuroprotection/CNPq |
| Identificador |
NEUROSCIENCE LETTERS, v.474, n.2, p.69-73, 2010 0304-3940 http://producao.usp.br/handle/BDPI/21519 10.1016/j.neulet.2010.02.067 |
| Idioma(s) |
eng |
| Publicador |
ELSEVIER IRELAND LTD |
| Relação |
Neuroscience Letters |
| Direitos |
restrictedAccess Copyright ELSEVIER IRELAND LTD |
| Palavras-Chave | #Purines #Guanosine #Inosine #Chronic pain #Cerebrospinal fluid #Somatic pain #GUANINE-BASED PURINES #NITRIC-OXIDE #AMINO-ACIDS #NEUROPATHIC PAIN #QUINOLINIC ACID #SPINAL-CORD #LABOR PAIN #GUANOSINE #ADENOSINE #MICE #Neurosciences |
| Tipo |
article original article publishedVersion |
