Loss of heterozygosity of the APC gene in oral squamous cell carcinoma
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
19/10/2012
19/10/2012
2008
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| Resumo |
The aim of this study was to investigate loss of heterozygosity (LOH) of the APC tumor suppressor gene loci, using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) in 40 cases of oral squamous cell carcinoma (OSCC). Observed informativity was 72.5% for APC exon 11 and 82.5% for APC exon 15. LOH at APC exon 11 was observed in 2 (6.9%) of 29 informative cases, and no LOH was observed for APC exon 15. Our results suggest that inactivation of the APC gene plays a minor role in the carcinogenesis of OSCC. (C) 2008 Elsevier GmbH. All rights reserved. FAPESP (The State of Sao Paulo Research Foundation)[01/03774-0] |
| Identificador |
PATHOLOGY RESEARCH AND PRACTICE, v.204, n.11, p.793-797, 2008 0344-0338 http://producao.usp.br/handle/BDPI/21481 10.1016/j.prp.2008.05.003 |
| Idioma(s) |
eng |
| Publicador |
ELSEVIER GMBH, URBAN & FISCHER VERLAG |
| Relação |
Pathology Research and Practice |
| Direitos |
restrictedAccess Copyright ELSEVIER GMBH, URBAN & FISCHER VERLAG |
| Palavras-Chave | #LOH #Genes, APC #Carcinoma, Squamous cell #PCR, RFLP #POLYPOSIS-COLI GENE #TUMOR-SUPPRESSOR GENES #INFREQUENT LOSS #NECK-CANCER #MCC GENES #HEAD #EXPRESSION #MUTATIONS #TISSUES #TAIWAN #Pathology |
| Tipo |
article original article publishedVersion |
