Search for Chronic Beryllium Disease Among Sarcoidosis Patients in Ontario, Canada
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
19/10/2012
19/10/2012
2011
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Resumo |
Chronic beryllium disease (CBD) is clinically similar to other granulomatous diseases such as sarcoidosis. It is often misdiagnosed if a thorough occupational history is not taken. When appropriate, a beryllium lymphocyte proliferation tests (BeLPT) need to be performed. We aimed to search for CBD among currently diagnosed pulmonary sarcoidosis patients and to identify the occupations and exposures in Ontario leading to CBD. Questionnaire items included work history and details of possible exposure to beryllium. Participants who provided a history of previous work with metals underwent BeLPTs and an ELISPOT on the basis of having a higher pretest probability of CBD. Among 121 sarcoid patients enrolled, 87 (72%) reported no known previous metal dust or fume exposure, while 34 (28%) had metal exposure, including 17 (14%) with beryllium exposure at work or home. However, none of these 34 who underwent testing had positive test results. Self-reported exposure to beryllium or metals was relatively common in these patients with clinical sarcoidosis, but CBD was not confirmed using blood assays in this population. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Brazil Workplace Safety and Insurance Board of Ontario (WSIB) Research Advisory Council |
Identificador |
LUNG, v.189, n.3, p.233-241, 2011 0341-2040 http://producao.usp.br/handle/BDPI/21307 10.1007/s00408-011-9285-4 |
Idioma(s) |
eng |
Publicador |
SPRINGER |
Relação |
Lung |
Direitos |
restrictedAccess Copyright SPRINGER |
Palavras-Chave | #Beryllium #Chronic beryllium disease #Sarcoidosis #Beryllium lymphocyte proliferation test #Medical surveillance #LYMPHOCYTE-PROLIFERATION TEST #CD4(+) T-CELLS #SENSITIZATION #FACILITY #FREQUENCY #RISK #Respiratory System |
Tipo |
article original article publishedVersion |