Search for Chronic Beryllium Disease Among Sarcoidosis Patients in Ontario, Canada


Autoria(s): RIBEIRO, Marcos; FRITSCHER, Leandro G.; AL-MUSAED, Ahmed M.; BALTER, Meyer S.; HOFFSTEIN, Victor; MAZER, Bruce D.; MAIER, Lisa A.; LISS, Gary M.; TARLO, Susan M.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2011

Resumo

Chronic beryllium disease (CBD) is clinically similar to other granulomatous diseases such as sarcoidosis. It is often misdiagnosed if a thorough occupational history is not taken. When appropriate, a beryllium lymphocyte proliferation tests (BeLPT) need to be performed. We aimed to search for CBD among currently diagnosed pulmonary sarcoidosis patients and to identify the occupations and exposures in Ontario leading to CBD. Questionnaire items included work history and details of possible exposure to beryllium. Participants who provided a history of previous work with metals underwent BeLPTs and an ELISPOT on the basis of having a higher pretest probability of CBD. Among 121 sarcoid patients enrolled, 87 (72%) reported no known previous metal dust or fume exposure, while 34 (28%) had metal exposure, including 17 (14%) with beryllium exposure at work or home. However, none of these 34 who underwent testing had positive test results. Self-reported exposure to beryllium or metals was relatively common in these patients with clinical sarcoidosis, but CBD was not confirmed using blood assays in this population.

Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Brazil

Workplace Safety and Insurance Board of Ontario (WSIB) Research Advisory Council

Identificador

LUNG, v.189, n.3, p.233-241, 2011

0341-2040

http://producao.usp.br/handle/BDPI/21307

10.1007/s00408-011-9285-4

http://dx.doi.org/10.1007/s00408-011-9285-4

Idioma(s)

eng

Publicador

SPRINGER

Relação

Lung

Direitos

restrictedAccess

Copyright SPRINGER

Palavras-Chave #Beryllium #Chronic beryllium disease #Sarcoidosis #Beryllium lymphocyte proliferation test #Medical surveillance #LYMPHOCYTE-PROLIFERATION TEST #CD4(+) T-CELLS #SENSITIZATION #FACILITY #FREQUENCY #RISK #Respiratory System
Tipo

article

original article

publishedVersion