Effect of phosphate binders on oxidative stress and inflammation markers in hemodialysis patients
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
---|---|
Data(s) |
19/10/2012
19/10/2012
2009
|
Resumo |
It has been suggested that phosphate binders may reduce the inflammatory state of hemodialysis (HD) patients. However, it is not clear whether it has any effect on oxidative stress. The objective of this study was to evaluate the effect of sevelamer hydrochloride (SH) and calcium acetate (CA) on oxidative stress and inflammation markers in HD patients. Hemodialysis patients were randomly assigned to therapy with SH (n=17) or CA (n=14) for 1 year. Before the initiation of therapy (baseline) and at 12 months, we measured in vitro reactive oxygen species (ROS) production by stimulated and unstimulated polymorphonuclear neutrophils and serum levels of tumor necrosis factor alpha, interleukin-10, C-reactive protein, and albumin. There was a significant reduction of spontaneous ROS production in both groups after 12 months of therapy. There was a significant decrease of Staphylococcus aureus stimulated ROS production in the SH group. There was a significant increase in albumin serum levels only in the SH group. In the SH group, there was also a decrease in the serum levels of tumor necrosis factor alpha and C-reactive protein. Our results suggest that compared with CA treatment, SH may lead to a reduction in oxidative stress and inflammation. Therefore, it is possible that phosphate binders exert pleiotropic effects on oxidative stress and inflammation, which could contribute toward decreasing endothelial injury in patients in HD. FAPESP (Fundacao de Amparo Pesquisa do Estado de Sao Paulo) Hospital do Rim e Hipertensao (Fundacao Oswaldo Ramos, SP, Brazil) Genzyme do Brasil |
Identificador |
HEMODIALYSIS INTERNATIONAL, v.13, n.3, p.271-277, 2009 1492-7535 http://producao.usp.br/handle/BDPI/21243 10.1111/j.1542-4758.2009.00369.x |
Idioma(s) |
eng |
Publicador |
WILEY-BLACKWELL PUBLISHING, INC |
Relação |
Hemodialysis International |
Direitos |
restrictedAccess Copyright WILEY-BLACKWELL PUBLISHING, INC |
Palavras-Chave | #Hemodialysis #phosphate binders #reactive oxygen species #inflammation #CHRONIC KIDNEY-DISEASE #SEVELAMER HYDROCHLORIDE #INDOXYL SULFATE #LIPID PROFILE #RENAL-FAILURE #CALCIFICATION #IMPACT #METABOLISM #PRODUCT #ACID #Urology & Nephrology |
Tipo |
article original article publishedVersion |