Biomimetic in silico devices


Autoria(s): Hunt, C.A.; Ropella, G. E. P.; Roberts, M. S.; Yan, L.
Data(s)

01/01/2005

Resumo

We introduce biomimetic in silico devices, and means for validation along with methods for testing and refining them. The devices are constructed from adaptable software components designed to map logically to biological components at multiple levels of resolution. In this report we focus on the liver; the goal is to validate components that mimic features of the lobule (the hepatic primary functional unit) and dynamic aspects of liver behavior, structure, and function. An assembly of lobule-mimetic devices represents an in silico liver. We validate against outflow profiles for sucrose administered as a bolus to isolated, perfused rat livers. Acceptable in silico profiles are experimentally indistinguishable from those of the in situ referent. This new technology is intended to provide powerful Dew tools for challenging our understanding of how biological functional units function in vivo.

Identificador

http://espace.library.uq.edu.au/view/UQ:47542

Idioma(s)

eng

Publicador

Springer-verlag Berlin

Palavras-Chave #Computer Science, Theory & Methods #Liver #Model #Rat #C1 #329902 Medical Biotechnology #329903 Therapies and Therapeutic Technology #730100 Clinical (Organs, Diseases and Abnormal Conditions)
Tipo

Journal Article